Preventive Effects of Monascus on Androgen-Related Diseases: Androgenetic Alopecia, Benign Prostatic Hyperplasia, and Prostate Cancer
| العنوان: | Preventive Effects of Monascus on Androgen-Related Diseases: Androgenetic Alopecia, Benign Prostatic Hyperplasia, and Prostate Cancer |
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| المؤلفون: | Hui Wen Chiu, Gwo Fang Yuan, Ming Der Wu, Yen-Lin Chen, Ming-Jiuan Wu, Mei-Huei Chen, Ying Jan Wang, Ching Ming Hung, Wen Hung Fang |
| المصدر: | Journal of Agricultural and Food Chemistry. 61:4379-4386 |
| بيانات النشر: | American Chemical Society (ACS), 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, Aging, medicine.medical_specialty, medicine.drug_class, Cancer Model, Prostatic Hyperplasia, Urology, Administration, Oral, urologic and male genital diseases, Rats, Sprague-Dawley, Mice, Prostate cancer, Prostate, medicine, Animals, Testosterone, biology, business.industry, Prostatic Neoplasms, Alopecia, Dihydrotestosterone, Methylnitrosourea, General Chemistry, Prostate-Specific Antigen, Hyperplasia, Androgen, medicine.disease, Monascus, biology.organism_classification, Rats, Mice, Inbred C57BL, medicine.anatomical_structure, Mice, Inbred CBA, General Agricultural and Biological Sciences, business, medicine.drug |
| الوصف: | Androgen-related diseases impair the well-being of many aging men. Unfortunately, the medications used to treat these diseases have many side effects. Therefore, there is a significant need for the development of novel drugs to treat androgen-related diseases. In this study, we investigated the effects of Monascus cursory extraction (M-CE) on androgen-related diseases, including androgenetic alopecia (AGA), benign prostatic hyperplasia (BPH) and prostate cancer. We found that M-CE suppressed baldness in male B6CBAF1/j mice. Furthermore, M-CE decreased PSA levels, indicating a protective effect of M-CE on testosterone-induced hyperplasia. M-CE also significantly decreased tumor volume and tumor incidence in an N-methyl-N-nitrosourea (MNU)/testosterone-induced rat prostate cancer model and markedly decreased dihydrotestosterone (DHT) but not testosterone. Additionally, PCNA expression was decreased in the prostate of rats treated with M-CE. These results suggest that M-CE could be a new potential therapeutic candidate for the treatment of androgen-related diseases. |
| تدمد: | 1520-5118 0021-8561 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ccc8c128d29ace8b0b9e5657220302Test https://doi.org/10.1021/jf400873wTest |
| رقم الانضمام: | edsair.doi.dedup.....e1ccc8c128d29ace8b0b9e5657220302 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15205118 00218561 |
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