Chemical Constituents and Their Bioactivities of Mushroom Phellinus rhabarbarinus
| العنوان: | Chemical Constituents and Their Bioactivities of Mushroom Phellinus rhabarbarinus |
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| المؤلفون: | Ji-Kai Liu, Xue-Mei Li, Zhong-Yu Zhou, Zheng-Hui Li, Jin-Long Cai, Tao Feng |
| المصدر: | Journal of Agricultural and Food Chemistry. 64:1945-1949 |
| بيانات النشر: | American Chemical Society (ACS), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | China, Antineoplastic Agents, Biology, Nitric Oxide, 01 natural sciences, Lanostane, Mice, chemistry.chemical_compound, Triterpenoid, Cell Line, Tumor, Ergosterol, Animals, Humans, Fruiting Bodies, Fungal, Medicine, Chinese Traditional, Mushroom, Phellinus rhabarbarinus, Molecular Structure, Traditional medicine, 010405 organic chemistry, Basidiomycota, Macrophages, General Chemistry, Triterpenes, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, RAW 264.7 Cells, chemistry, Chemical constituents, General Agricultural and Biological Sciences, Human cancer |
| الوصف: | Phellinus rhabarbarinus soaked in wine has folk usages by local residents of Ailao mountain of Yunnan province, China, which were to daub the wound to prevent infection and to drink to enhance immunity and treat other diseases such as cough, gastritis, and cancer. Systemic investigation on the chemical constituents of fruiting bodies of P. rhabarbarinus resulted in the isolation of 11 lanostane triterpenoids (1-10) including three new ones, namely, phellibarins A-C (1-3), together with five ergosterols (11-15). This is the first time reporting secondary metabolites of P. rhabarbarinus. Compounds 2, 3, 7, and 8 showed inhibitory activities against nitric oxide (NO) production in LPS-activated RAW264.7 macrophages, whereas compounds 2-4, 6, 7, and 10 exhibited cytotoxicities against human cancer cell lines. The results of this assessment suggested that the lanostane triterpenoids in fruiting bodies of P. rhabarbarinus played key roles in its folk usages. |
| تدمد: | 1520-5118 0021-8561 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba5306426ffd58f0ace54c0bf984714Test https://doi.org/10.1021/acs.jafc.6b00176Test |
| رقم الانضمام: | edsair.doi.dedup.....6ba5306426ffd58f0ace54c0bf984714 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15205118 00218561 |
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