Oxytocin and bone remodelling: relationships with neuropituitary hormones, bone status and body composition
| العنوان: | Oxytocin and bone remodelling: relationships with neuropituitary hormones, bone status and body composition |
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| المؤلفون: | Georges F. Carle, Patricia Panaia-Ferrari, Gérard Ailhaud, Christian Dani, Liana Euller-Ziegler, Véronique Breuil, Christian Elabd, Christian Roux, Jean Testa, Christine Albert-Sabonnadière, Ez-Zoubir Amri |
| المساهمون: | Génétique, physiopathologie et ingénierie du tissu osseux (GéPITOS), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Service de rhumatologie, Centre Hospitalier Universitaire de Nice (CHU Nice)-Hôpital l'Archet, Institute of Developmental Biology and Cancer (IBDC), Institut de Biologie Valrose (IBV), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), CHU de Nice, Risques, Epidémiologie, Territoire, INformations, Education et Santé (RETINES), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Centre Hospitalier Universitaire de Nice (CHU Nice), Institut de signalisation, biologie du développement et cancer (ISBDC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Hôpital Pasteur [Nice] (CHU) |
| المصدر: | Joint Bone Spine Joint Bone Spine, Elsevier Masson, 2011, epub ahead of print. ⟨10.1016/j.jbspin.2011.02.002⟩ ISABB Journal of Health and Environmental Sciences ISABB Journal of Health and Environmental Sciences, Academic Journals, 2011, 78 (6), pp.611-615. ⟨10.5897/ISABB-JHE⟩ |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Leptin, Osteoporosis, Oxytocin, Severity of Illness Index, Bone remodeling, 0302 clinical medicine, Sex hormone-binding globulin, Bone Density, Sex Hormone-Binding Globulin, [SDV.BDD]Life Sciences [q-bio]/Development Biology, ComputingMilieux_MISCELLANEOUS, Osteoporosis, Postmenopausal, Bone mineral, Aged, 80 and over, 0303 health sciences, biology, Estradiol, Oxytocin secretion, Middle Aged, 3. Good health, Body Composition, Female, Bone Remodeling, hormones, hormone substitutes, and hormone antagonists, medicine.drug, medicine.medical_specialty, endocrine system, 030209 endocrinology & metabolism, Collagen Type I, 03 medical and health sciences, Rheumatology, N-terminal telopeptide, Internal medicine, medicine, Humans, 030304 developmental biology, Aged, Retrospective Studies, business.industry, Luteinizing Hormone, medicine.disease, Pituitary Hormones, Endocrinology, Case-Control Studies, biology.protein, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Peptides |
| الوصف: | International audience; PURPOSE: There is growing evidence that oxytocin, which regulates appetite, plays a role in bone remodelling and improves osteoporosis. We previously showed a significant decrease in circulating oxytocin levels in postmenopausal osteoporotic women compared to healthy controls. However, factors involved in the pathophysiology of osteoporosis, such as estrogens and leptin, are known to regulate oxytocin secretion. Herein, we evaluated the relationships between oxytocin and other hormonal factors known to regulate bone remodeling and body composition in postmenopausal osteoporotic women, compared to healthy controls. METHODS: In 20 postmenopausal women with severe osteoporosis compared to 16 healthy controls, we measured serum levels of oxytocin, high sensitive estradiol, testosterone, FSH, LH, SHBG, TSH, osteocalcin, serum type I collagen carboxy-terminal telopeptide, leptin. Bone mineral density and body composition were also measured with DXA. RESULTS: Osteoporotic women had significantly lower oxytocin, leptin and LH serum levels and higher CTX and SHBG; all other biological parameters were similar in both groups. Fat mass and lean mass were significantly decreased in osteoporotic women. Oxytocin serum levels were significantly correlated to bone mineral density but not to any other measured parameter, including leptin, estradiol and age. In a logistic regression analysis, osteoporosis remained significantly correlated to oxytocin, regardless of age. CONCLUSIONS: Low oxytocin serum levels appeared to be associated with severe osteoporosis, independently of other factors associated with osteoporosis or known to regulate oxytocin serum levels, such as estradiol or leptin, reinforcing the concept that oxytocin may be involved in the pathophysiology of postmenopausal osteoporosis. |
| تدمد: | 1778-7254 1297-319X 1937-3236 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5beda8a55b42ff8611e5e4b8fade8b6Test https://pubmed.ncbi.nlm.nih.gov/21441053Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....d5beda8a55b42ff8611e5e4b8fade8b6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17787254 1297319X 19373236 |
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