التفاصيل البيبلوغرافية
| العنوان: |
Validation of the NSABP/NRG Oncology 8-Gene Trastuzumab-benefit Signature in Alliance/NCCTG N9831. |
| المؤلفون: |
Pogue-Geile, Katherine L, Song, Nan, Serie, Daniel J, Wang, Ying, Gavin, Patrick G, Kim, Rim S, Tanaka, Noriko, Fumagalli, Debora, Taniyama, Yusuke, Li, Zhuo, Rastogi, Priya, Swain, Sandra M, Mamounas, Eleftherios P, Geyer, Charles E, Wolmark, Norman, Lucas, Peter C, Paik, Soonmyung, Thompson, E Aubrey |
| المصدر: |
JNCI Cancer Spectrum; Oct2020, Vol. 4 Issue 5, p1-4, 4p |
| مصطلحات موضوعية: |
TRASTUZUMAB, CANCER chemotherapy, ESTROGEN receptors, PROGESTERONE receptors, TUMORS |
| مستخلص: |
Our objective was to validate the NSABP 8-gene trastuzumab-benefit signature, developed and initially validated in NRG Oncology/NSABP B-31 in Alliance/NCCTG N9831. The B-31 and N9831 trials demonstrated the benefit of adding trastuzumab to chemotherapy in the adjuvant setting for HER2+ breast cancer patients. NSABP investigators utilized gene expression profiles of N9831 patients (N = 892) to blindly assign patients to large-, moderate-, or no-trastuzumab benefit groups and then NCCTG investigators assessed the degree of trastuzumab benefit using Cox models adjusted for age, nodes, estrogen receptor/progesterone receptor status, tumor size, and grade. Hazard ratios and 2-sided P values for recurrence-free survival of the predicted large- (n = 387), moderate- (n = 401), and no-benefit (n = 104) groups, based on the 8-gene signature were 0.47 (95% CI = 0.31 to 0.73, P <.001), 0.60 (95% CI = 0.39 to 0.92, P =.02), and 1.54 (95% CI = 0.59 to 4.02, P =.38), respectively (P interaction =.02), providing validation of the 8-gene signature in an independent study. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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