دورية أكاديمية
The hypoglicemic effects of tapak liman (Elephantopus scaber L) plant extract on albino rat (Rattus novergicus) models of diabetes mellitus
| العنوان: | The hypoglicemic effects of tapak liman (Elephantopus scaber L) plant extract on albino rat (Rattus novergicus) models of diabetes mellitus |
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| المؤلفون: | Tri Agusti Sholikah, Sri Wulandari, Indah Ariesta, Muhammad Arif Rakhman Hakim, Muhammad Hafizhan |
| المصدر: | JKKI (Jurnal Kedokteran dan Kesehatan Indonesia), Pp 172-179 (2020) |
| بيانات النشر: | Faculty of Medicine, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | elephantopus scaber l, flavanoid, dm rat model, Medicine |
| الوصف: | Background: Diabetes mellitus (DM) is among the diseases with high morbidity and mortality The pathogenesis of DM involves pancreatic ß-cell damage or insulin sensitivity disorder that result in hyperglycemia. Tapak liman (Elephantopus scaber L) is known to have high flavonoid content. Flavonoids are antioxidants that play a role in reducing pancreatic ß-cell damage or damage to other tissues, which potentially reduce blood glucose levels. Objective: To determine the hypoglycemic effects of tapak liman using the DM rat models. Methods: Twenty-eight Wistar albino rats (Rattus novergicus) were divided into four groups: the normal control group (KKn), not induced by streptozotocin-nicotinamide (STZ-NA) intraperitoneal; negative control group (KK-), induced by STZ-NA; treatment group 1 (KP1), induced by STZ-NA and 150 mg/kg body weight of tapak liman plant extract; and the treatment group 2 (KP2), induced by STZ-NA and 300 mg/kg body weight of tapak liman. Blood glucose levels were measured on the 7th day after STZ-NA induction and the 28th day after the administration of tapak liman plant extract. The results were analyzed for statistical significance. Results: There was a significant decrease in blood glucose levels in KP1 and KP2 (p= 0.05). The decrease in blood glucose in KP1 had not reached normal levels compared to KP2. Conclusion: Administration of tapak liman plant extract at a dose of 300 mg/kg body weight in DM rat models reduced blood glucose levels to normal. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2085-4145 2527-2950 |
| العلاقة: | https://journal.uii.ac.id/JKKI/article/view/13115Test; https://doaj.org/toc/2085-4145Test; https://doaj.org/toc/2527-2950Test |
| DOI: | 10.20885/JKKI.Vol11.Iss2.art10 |
| الوصول الحر: | https://doaj.org/article/a641db96fae84316b717559942ab67bfTest |
| رقم الانضمام: | edsdoj.641db96fae84316b717559942ab67bf |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 20854145 25272950 |
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| DOI: | 10.20885/JKKI.Vol11.Iss2.art10 |