نتائج البحث

21

Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target

المؤلفون: Mark A. Morgan, Robert A. Burger, Mireia Uribe-Herranz, Stefano Pierini, Erin George, Fiona Simpkins, Janos L. Tanyi, Andrea Facciabene, Ronny Drapkin

المصدر: JCI Insight, Vol 5, Iss 16 (2020)
JCI Insight

مصطلحات موضوعية: 0301 basic medicine, Adult, Forkhead Box Protein L2, medicine.medical_treatment, Population, Programmed Cell Death 1 Receptor, Immunology, Immune Targeting, Cancer immunotherapy, Mice, Inbred Strains, Cancer Vaccines, 03 medical and health sciences, Epitopes, 0302 clinical medicine, Immune system, Lymphocytes, Tumor-Infiltrating, Pregnancy, Cell Line, Tumor, Immune Tolerance, Tumor Microenvironment, Vaccines, DNA, Medicine, Animals, Humans, education, Immune Checkpoint Inhibitors, Granulosa Cell Tumor, education.field_of_study, business.industry, Tumor-infiltrating lymphocytes, General Medicine, Middle Aged, Xenograft Model Antitumor Assays, 030104 developmental biology, Forkhead box L2, Immunization, Oncology, Tumor progression, 030220 oncology & carcinogenesis, Cancer research, Female, business, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::255c99bb3ed436759c3786738dc4cef4Test
https://doaj.org/article/3ee8feab99b74b3781439e0dd4109565Test

22

Cell type-specific immune phenotypes predict loss of insulin secretion in new-onset type 1 diabetes

المؤلفون: Peter S. Linsley, Matthew J. Dufort, Cate Speake, Carla J. Greenbaum

المصدر: JCI insight. 4(4)

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Adolescent, medicine.medical_treatment, Cell, medicine.disease_cause, Autoimmunity, 03 medical and health sciences, Leukocyte Count, Young Adult, 0302 clinical medicine, Immune system, Diabetes mellitus, Insulin-Secreting Cells, Insulin Secretion, medicine, Leukocytes, Humans, Immunologic Factors, Insulin, RNA-Seq, Child, B cell, Whole blood, Type 1 diabetes, business.industry, Patient Selection, Age Factors, General Medicine, Immunotherapy, Middle Aged, medicine.disease, Prognosis, 030104 developmental biology, medicine.anatomical_structure, Diabetes Mellitus, Type 1, Treatment Outcome, 030220 oncology & carcinogenesis, Immunology, Disease Progression, Female, Controlled Clinical Trials as Topic, business, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990915c53d815e1cfbba0269fecdd958Test
https://pubmed.ncbi.nlm.nih.gov/30830868Test

23

β Cell dysfunction exists more than 5 years before type 1 diabetes diagnosis

المؤلفون: Heba M. Ismail, Jay M. Sosenko, Carmella Evans-Molina, Susan Geyer, Ping Xu, Jeffrey P. Krischer, Jerry P. Palmer, Linda A. DiMeglio, Emily K. Sims, Andrea K. Steck

المصدر: JCI Insight. 3

مصطلحات موضوعية: Adult, Blood Glucose, Male, 0301 basic medicine, endocrine system, Allergy, medicine.medical_specialty, Time Factors, endocrine system diseases, Adolescent, medicine.medical_treatment, Cell, 030209 endocrinology & metabolism, Child health, Young Adult, 03 medical and health sciences, 0302 clinical medicine, immune system diseases, Insulin-Secreting Cells, Internal medicine, Diabetes mellitus, medicine, Humans, Longitudinal Studies, Prospective Studies, Child, Autoantibodies, Type 1 diabetes, Kidney, C-Peptide, business.industry, Insulin, nutritional and metabolic diseases, Fasting, General Medicine, Glucose Tolerance Test, medicine.disease, Clinical trial, Diabetes Mellitus, Type 1, 030104 developmental biology, medicine.anatomical_structure, Child, Preschool, Disease Progression, Female, Clinical Medicine, business, Follow-Up Studies

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e05157a96e533cd8bff8a2effe6bef0Test
https://doi.org/10.1172/jci.insight.120877Test

24

Longitudinal COVID-19 profiling associates IL-1RA and IL-10 with disease severity and RANTES with mild disease

المؤلفون: Bin Xu, Jianping Sun, Ling Qin, A J McMichael, Julian C. Knight, P Zhang, A Li, Graham S. Ogg, Yanchun Peng, Tao Dong, Haiping Xiang, Ho L-P., Xuemei Li, Chunpan Zhang, Lianchun Liang, Zhongjie Hu, Kang Li, Ronghua Jin, Yingmei Feng, Yonghong Zhang, Yanchao Dai, Yan Zhao

المصدر: JCI Insight

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Chemokine, Vaccine evaluation, medicine.medical_treatment, Pneumonia, Viral, Severity of Illness Index, CCL5, Betacoronavirus, Interferon-gamma, 03 medical and health sciences, 0302 clinical medicine, Severity of illness, medicine, Humans, Longitudinal Studies, Chemokine CCL5, Pandemics, Aged, Immunoassay, biology, Interleukin-6, SARS-CoV-2, Tumor Necrosis Factor-alpha, business.industry, Case-control study, COVID-19, Granulocyte-Macrophage Colony-Stimulating Factor, General Medicine, Middle Aged, medicine.disease, Interleukin-10, Hospitalization, Interleukin 1 Receptor Antagonist Protein, Interleukin 10, 030104 developmental biology, Cytokine, Case-Control Studies, 030220 oncology & carcinogenesis, Immunology, biology.protein, Female, Coronavirus Infections, Cytokine Release Syndrome, Cytokine storm, business, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f4c36dd61aca4ac81a5ac3cc6f27d8Test
https://doi.org/10.1172/jci.insight.139834Test

25

Combination of host immune metabolic biomarkers for the PD-1 blockade cancer immunotherapy

المؤلفون: Tasuku Honjo, Toyohiro Hirai, Yuichi Sakamori, Yasushi Okuno, Maryam Akrami, Fumihiko Matsuda, Ryusuke Hatae, Hiroaki Ozasa, Hironori Yoshida, Kazuhiro Sonomura, Kenji Chamoto, Kei Taneishi, Shuji Kawaguchi, Sidonia Fagarasan, Izuru Masuda, Young Hak Kim

المصدر: JCI Insight. 5

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Lung Neoplasms, Metabolite, medicine.medical_treatment, T cell, Programmed Cell Death 1 Receptor, 03 medical and health sciences, chemistry.chemical_compound, Antineoplastic Agents, Immunological, 0302 clinical medicine, Immune system, Cancer immunotherapy, Carcinoma, Non-Small-Cell Lung, Carnitine, Biomarkers, Tumor, Humans, Medicine, Prospective Studies, Beta oxidation, Aged, Aged, 80 and over, Glutathione Disulfide, business.industry, Hippurates, Microbiota, General Medicine, Middle Aged, Nivolumab, 030104 developmental biology, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, Cancer research, Glutathione disulfide, Drug Therapy, Combination, Female, Immunotherapy, Clinical Medicine, Energy Metabolism, business, CD8

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0f8b83c0a144f9febe31ec1f05c62abTest
https://doi.org/10.1172/jci.insight.133501Test

26

TCF-1 regulates HIV-specific CD8+ T cell expansion capacity

المصدر: JCI Insight
JCI Insight, Vol 6, Iss 3 (2021)
JCI insight, vol 6, iss 3

مصطلحات موضوعية: 0301 basic medicine, Male, HIV Antigens, Human immunodeficiency virus (HIV), Simian Acquired Immunodeficiency Syndrome, HIV Infections, CD8-Positive T-Lymphocytes, medicine.disease_cause, Gene Knockout Techniques, 0302 clinical medicine, Stem Cell Research - Nonembryonic - Human, T Cell Transcription Factor 1, Cytotoxic T cell, Effector, Simian immunodeficiency virus, General Medicine, Middle Aged, Viral Load, Acquired immune system, Cell biology, medicine.anatomical_structure, Infectious Diseases, 030220 oncology & carcinogenesis, HIV/AIDS, Medicine, Female, Simian Immunodeficiency Virus, Infection, Research Article, Adult, T cell, 1.1 Normal biological development and functioning, Immunology, Adaptive immunity, T cells, Biology, Virus, AIDS/HIV, 03 medical and health sciences, Underpinning research, medicine, Animals, Humans, Transcription factor, Aged, Stem Cell Research, Macaca mulatta, 030104 developmental biology, Good Health and Well Being, HIV-1, Immunologic Memory, CD8

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::929b63af29587eb6cb7889bf025bb4cbTest
https://pubmed.ncbi.nlm.nih.gov/33351785Test

27

Multiplexing DNA methylation markers to detect circulating cell-free DNA derived from human pancreatic β cells

المصدر: JCI Insight

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b8f2ba333c23763547fe0ffea2f33edTest
https://pubmed.ncbi.nlm.nih.gov/32573495Test

28

IL-1RA regulates immunopathogenesis during fungal-associated allergic airway inflammation

المؤلفون: Deborah A. Meyers, Matthew S. Godwin, Annette T. Hastie, Chad Steele, Sadis Matalon, Jonathan P. Blackburn, Zhihong Yu, Jaleesa M. Garth, MaryJane Jones, Kristen M. Reeder

المصدر: JCI Insight. 4

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Allergy, Interleukin-1beta, Atopy, Mice, 03 medical and health sciences, 0302 clinical medicine, Interleukin-1alpha, Hypersensitivity, medicine, Animals, Humans, Asthma, Anakinra, medicine.diagnostic_test, business.industry, Fungi, Sputum, General Medicine, medicine.disease, respiratory tract diseases, Mice, Inbred C57BL, Interleukin 1 Receptor Antagonist Protein, 030104 developmental biology, Bronchoalveolar lavage, Bronchial hyperresponsiveness, 030220 oncology & carcinogenesis, Immunology, Female, Methacholine, Bronchial Hyperreactivity, medicine.symptom, business, Bronchoalveolar Lavage Fluid, Signal Transduction, Research Article, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a375742536967c364aca7c4763e546f8Test
https://doi.org/10.1172/jci.insight.129055Test

29

PD-1hiCXCR5– T peripheral helper cells promote B cell responses in lupus via MAF and IL-21

المصدر: JCI Insight. 4

مصطلحات موضوعية: Adult, Male, Receptors, CXCR5, T cell, Programmed Cell Death 1 Receptor, Cell, Cell Culture Techniques, Lupus nephritis, CD11c, Cell Communication, Cell Separation, Biology, Lymphocyte Activation, medicine.disease_cause, Autoimmunity, Gene Knockout Techniques, medicine, Humans, Lupus Erythematosus, Systemic, RNA-Seq, skin and connective tissue diseases, Cells, Cultured, B cell, Aged, B-Lymphocytes, Systemic lupus erythematosus, Interleukins, T-Lymphocytes, Helper-Inducer, General Medicine, Middle Aged, Flow Cytometry, medicine.disease, Acquired immune system, Coculture Techniques, CD11c Antigen, medicine.anatomical_structure, Case-Control Studies, Proto-Oncogene Proteins c-maf, Immunology, Female, CRISPR-Cas Systems, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a61663fe044736e00a73ee86f853a65Test
https://doi.org/10.1172/jci.insight.130062Test

30

Robust surgical approach for cutaneous neurofibroma in neurofibromatosis type 1

المؤلفون: Lu Q. Le, Juan Vega, Dezehree Solorzano, La’Nette Hernandez, Bahir H. Chamseddin

المصدر: JCI Insight. 4

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c671c7751016921538509ba54c5fc165Test
https://doi.org/10.1172/jci.insight.128881Test

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