نتائج البحث

1

Fatty acid binding protein 4 promotes autoimmune diabetes by recruitment and activation of pancreatic islet macrophages

المؤلفون: Lai Yee Cheong, Ruby L. C. Hoo, Xiaoyu Xiao, Yang Liu, Yang Xiao, Zhiguang Zhou, Boya Liao, Aimin Xu, Xiaoping Wu, Lingling Shu

المصدر: JCI Insight, Vol 6, Iss 7 (2021)
JCI Insight

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Adoptive cell transfer, T-Lymphocytes, Autoimmunity, medicine.disease_cause, Fatty Acid-Binding Proteins, Diabetes Mellitus, Experimental, 03 medical and health sciences, Islets of Langerhans, 0302 clinical medicine, Immune system, Endocrinology, Mice, Inbred NOD, Medicine, Animals, Humans, Benzothiazoles, NOD mice, Autoantibodies, Bone Marrow Transplantation, Innate immunity, Type 1 diabetes, geography, geography.geographical_feature_category, Innate immune system, business.industry, Macrophages, Diabetes, Autoantibody, General Medicine, Carbocyanines, Middle Aged, medicine.disease, Islet, Mice, Mutant Strains, 030104 developmental biology, Diabetes Mellitus, Type 1, 030220 oncology & carcinogenesis, Immunology, Female, business, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b49e44f810f16457012d14ea324cf550Test
https://doaj.org/article/4cae76f959a34aa7a137d440a57963ccTest

2

Brain functions and cognition on transient insulin deprivation in type 1 diabetes

المؤلفون: John D. Port, Tiffany Cortes, Gregory N. Ruegsegger, Ana L. Creo, Andrea R.S. Huebner, Yogish C. Kudva, Aida N. Lteif, Katherine A. Klaus, Surendra Dasari, K. Sreekumaran Nair, Hang Joon Jo, Ronald C. Petersen, Jan Mendelt Tillema

المصدر: JCI Insight, Vol 6, Iss 5 (2021)
JCI Insight

مصطلحات موضوعية: Adult, Blood Glucose, Male, 0301 basic medicine, medicine.medical_specialty, medicine.medical_treatment, Pilot Projects, Phosphocreatine, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Memory, Diabetes mellitus, Internal medicine, Fractional anisotropy, medicine, Insulin, Humans, Dementia, Cognitive Dysfunction, Sensory cortex, Translational Science, Biomedical, Type 1 diabetes, business.industry, Diabetes, Cognition, Somatosensory Cortex, General Medicine, medicine.disease, Diabetes Mellitus, Type 1, 030104 developmental biology, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, Medicine, Female, Clinical Medicine, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df35e605fd35bca18e9e9717df343f45Test
https://doaj.org/article/89e91ea96c224a14803019bb961e2cc3Test

3

CD4+CD25+CD127hi cell frequency predicts disease progression in type 1 diabetes

المؤلفون: Mark Harris, Ranjeny Thomas, Martin J. Hessner, Rhonda Geoffrey, Anne-Sophie Bergot, Breanna Lam, Kerry Buchanan, Elisavet Serti, Rosita Moya, Alessandra Mandelli, Irene Gotuzzo, Manuela Battaglia, Joanna D. Davies, Aditi Narsale, Benedetta Pessina, Gian Maria Giamporcaro, TingTing Lu

المصدر: JCI Insight, Vol 6, Iss 2 (2021)
JCI Insight

مصطلحات موضوعية: CD4-Positive T-Lymphocytes, Male, 0301 basic medicine, Oncology, Autoimmune diseases, medicine.medical_treatment, Cell, Autoimmunity, medicine.disease_cause, 0302 clinical medicine, T-Lymphocyte Subsets, IL-2 receptor, Child, education.field_of_study, Diabetes, General Medicine, medicine.anatomical_structure, Child, Preschool, 030220 oncology & carcinogenesis, Disease Progression, Medicine, Female, Immunotherapy, Research Article, medicine.drug, Adult, medicine.medical_specialty, Adolescent, Population, Immunology, T cells, Alefacept, Interleukin-7 Receptor alpha Subunit, Young Adult, 03 medical and health sciences, Diabetes mellitus, Internal medicine, medicine, Humans, education, Proportional Hazards Models, Type 1 diabetes, business.industry, Interleukin-2 Receptor alpha Subunit, Infant, medicine.disease, Diabetes Mellitus, Type 1, 030104 developmental biology, Multivariate Analysis, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18ca9272dda4aa45bece327b8ae55f8Test
https://doaj.org/article/20ba8c4ce6b4454ea7c69dca229e3557Test

4

Phenotypic heterogeneity of neurofibromatosis type 1 in a large international registry

المؤلفون: Shufeng Li, Annette Bakker, Kavita Y. Sarin, Mika M. Tabata, Pamela Knight

المصدر: JCI Insight, Vol 5, Iss 16 (2020)
JCI Insight

مصطلحات موضوعية: 0301 basic medicine, Adult, Pathology, medicine.medical_specialty, congenital, hereditary, and neonatal diseases and abnormalities, Neurofibromatosis 1, Adolescent, Malignant peripheral nerve sheath tumor, Comorbidity, Dermatology, Spinal neurofibromas, 03 medical and health sciences, Young Adult, 0302 clinical medicine, medicine, Prevalence, Neurofibroma, Humans, Genetic variation, Registries, Neurofibromatosis, neoplasms, Aged, Neurofibromin 1, business.industry, Genetic heterogeneity, Genetic disorder, General Medicine, Phenotypic trait, Middle Aged, medicine.disease, nervous system diseases, 030104 developmental biology, Phenotype, Dysplasia, 030220 oncology & carcinogenesis, Mutation, Medicine, business, Neurological disorders, Research Article, Genetic diseases, Neuroscience

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2985be0c1f54c8a1ca7f5cb518d27dTest
https://doaj.org/article/097c0850c842415abb2e9486dc716821Test

5

Pancreas tissue slices from organ donors enable in situ analysis of type 1 diabetes pathogenesis

المصدر: JCI insight 5:134525 (2020)
JCI Insight

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Cell physiology, endocrine system, Pathology, medicine.medical_specialty, Adolescent, endocrine system diseases, Cell, Enteroendocrine cell, medicine.disease_cause, Autoimmunity, Tissue Culture Techniques, Pathogenesis, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Insulin-Secreting Cells, Diabetes mellitus, medicine, Humans, Child, Pancreas, Autoimmune Diseases, Beta Cells, Diabetes, Endocrinology, Type 1 diabetes, business.industry, General Medicine, medicine.disease, Tissue Donors, Diabetes Mellitus, Type 1, 030104 developmental biology, medicine.anatomical_structure, Technical Advance, Child, Preschool, 030220 oncology & carcinogenesis, Female, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f63476339e1164c9eeceb0ad18778170Test
https://doi.org/10.1172/jci.insight.134525Test

6

Immunomodulatory activity of humanized anti–IL-7R monoclonal antibody RN168 in subjects with type 1 diabetes

المؤلفون: Kevan C. Herold, Gilbert Y. Wong, Tenshang Joh, Shobha Potluri, Peter A. Gottlieb, Bruce W. Bode, Matteo Levisetti, Janet B. McGill, Megan Shannon, Bishu J Ganguly, Jing W. Hughes, Samantha L. Bucktrout, Desmond A. Schatz, Stephen E. Gitelman, Jeremy Pettus, Xiao Wang, Pamela D. Garzone, Chandrasekhar Udata

المصدر: JCI Insight. 4

مصطلحات موضوعية: Adult, CD4-Positive T-Lymphocytes, Male, 0301 basic medicine, Cell Survival, medicine.drug_class, medicine.medical_treatment, T cell, Dose-Response Relationship, Immunologic, CD8-Positive T-Lymphocytes, Antibodies, Monoclonal, Humanized, Monoclonal antibody, Interleukin-7 Receptor alpha Subunit, 03 medical and health sciences, 0302 clinical medicine, Immune system, medicine, Humans, Type 1 diabetes, Dose-Response Relationship, Drug, biology, business.industry, Interleukin-7, General Medicine, Middle Aged, medicine.disease, Diabetes Mellitus, Type 1, Treatment Outcome, 030104 developmental biology, Cytokine, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Immunology, Monoclonal, biology.protein, Female, Antibody, business, Immunologic Memory, CD8, Signal Transduction, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406708a6949f1f766cbebb2d99dd6f96Test
https://doi.org/10.1172/jci.insight.126054Test

7

Chromosome 8 gain is associated with high-grade transformation in MPNST

المصدر: JCI Insight, Vol 6, Iss 6 (2021)
JCI Insight

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75196857babffae439e3abe5a5613bbdTest
https://doaj.org/article/02174fc3c80343d29dc12bc04c3f1439Test

8

Profiling of patients with glioma reveals the dominant immunosuppressive axis is refractory to immune function restoration

المصدر: JCI Insight
JCI Insight, Vol 5, Iss 17 (2020)

مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Cancer immunotherapy, Brain cancer, Mice, 0302 clinical medicine, 5'-Nucleotidase, Immune Checkpoint Inhibitors, Cells, Cultured, Brain Neoplasms, Apyrase, Glioma, General Medicine, Middle Aged, Isocitrate Dehydrogenase, Oncology, 030220 oncology & carcinogenesis, Medicine, Female, Immunosuppressive Agents, Research Article, medicine.drug, Adult, IDH1, Receptor, Adenosine A2A, Immunology, 03 medical and health sciences, Immune system, Downregulation and upregulation, Antigens, CD, Cell Line, Tumor, medicine, Animals, Humans, Aged, business.industry, Therapeutic effect, medicine.disease, Adenosine, Adenosine receptor, Mice, Inbred C57BL, 030104 developmental biology, Cancer research, Neoplasm Grading, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1b7362d1d0c19278cd2192b48b6dbf5Test
https://doi.org/10.1172/jci.insight.134386Test

9

Regulation of glycolysis and the Warburg effect in wound healing

المؤلفون: Dalia Barayan, Abdikarim Abdullahi, Christopher Auger, Roohi Vinaik, Marc G. Jeschke

المصدر: JCI Insight
JCI Insight, Vol 5, Iss 17 (2020)

مصطلحات موضوعية: Male, 0301 basic medicine, Inflammasomes, Mice, 0302 clinical medicine, Keloid, Glycolysis, skin and connective tissue diseases, Skin, Mice, Knockout, Glucose metabolism, Glucose Transporter Type 1, Anti-Inflammatory Agents, Non-Steroidal, Inflammasome, General Medicine, Middle Aged, Warburg effect, 3. Good health, 030220 oncology & carcinogenesis, Medicine, Female, Inflammation Mediators, medicine.symptom, Burns, Research Article, medicine.drug, Adult, Pyruvate Kinase, Inflammation, Therapeutics, 03 medical and health sciences, NLR Family, Pyrin Domain-Containing 3 Protein, medicine, Animals, Humans, Wound Healing, business.industry, medicine.disease, Mice, Inbred C57BL, 030104 developmental biology, Anaerobic glycolysis, Case-Control Studies, Cancer research, Wound healing, business, Pyruvate kinase, Naphthoquinones

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df55c86a285b8b6069855b42530f20bbTest
https://doi.org/10.1172/jci.insight.138949Test

10

Cell type-specific immune phenotypes predict loss of insulin secretion in new-onset type 1 diabetes

المؤلفون: Peter S. Linsley, Matthew J. Dufort, Cate Speake, Carla J. Greenbaum

المصدر: JCI insight. 4(4)

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Adolescent, medicine.medical_treatment, Cell, medicine.disease_cause, Autoimmunity, 03 medical and health sciences, Leukocyte Count, Young Adult, 0302 clinical medicine, Immune system, Diabetes mellitus, Insulin-Secreting Cells, Insulin Secretion, medicine, Leukocytes, Humans, Immunologic Factors, Insulin, RNA-Seq, Child, B cell, Whole blood, Type 1 diabetes, business.industry, Patient Selection, Age Factors, General Medicine, Immunotherapy, Middle Aged, medicine.disease, Prognosis, 030104 developmental biology, medicine.anatomical_structure, Diabetes Mellitus, Type 1, Treatment Outcome, 030220 oncology & carcinogenesis, Immunology, Disease Progression, Female, Controlled Clinical Trials as Topic, business, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990915c53d815e1cfbba0269fecdd958Test
https://pubmed.ncbi.nlm.nih.gov/30830868Test

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