Clinical Analysis of Thymic Regrowth Following Chemotherapy in Children and Adolescents with Malignant Lymphoma
| العنوان: | Clinical Analysis of Thymic Regrowth Following Chemotherapy in Children and Adolescents with Malignant Lymphoma |
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| المؤلفون: | Jia-yu Ling, Zhongzhen Guan, Yue Cai, Yi Xia, Juan Wang, Xiaofei Sun, Zijun Zhen |
| المصدر: | Japanese Journal of Clinical Oncology. 40:1128-1134 |
| بيانات النشر: | Oxford University Press (OUP), 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Male, Cancer Research, medicine.medical_specialty, Time Factors, Adolescent, Lymphoma, medicine.medical_treatment, Standardized uptake value, Thymus Gland, Disease-Free Survival, Fluorodeoxyglucose F18, Antineoplastic Combined Chemotherapy Protocols, medicine, Medical imaging, Humans, Radiology, Nuclear Medicine and imaging, Child, Fluorodeoxyglucose, Chemotherapy, Clinical pathology, medicine.diagnostic_test, business.industry, General Medicine, medicine.disease, Chemotherapy regimen, Oncology, Positron emission tomography, Child, Preschool, Positron-Emission Tomography, Lymph Nodes, Radiology, Radiopharmaceuticals, Tomography, X-Ray Computed, business, Follow-Up Studies, medicine.drug |
| الوصف: | Objectives: Thymic regrowth following chemotherapy has typical clinical and imaging manifestations that can be used to diagnose it prior to pathological diagnosis. We investigated methods for diagnosing thymic regrowth following chemotherapy with non-invasive methods. Methods: Our study included 26 children and adolescents with thymic regrowth following chemotherapy for malignant lymphoma. Computed tomography scans were routinely performed for follow-up observations. After the emergence of new mediastinal masses, patients either underwent Fluorine-18 fluorodeoxyglucose-positron emission tomography scans to identify the characteristics of the mass, or were closely followed up. Results: Thymic regrowth occurred 1‐12 months after the last chemotherapy (mean, 4 months). Computed tomography mostly revealed diffusely enlarged thymic parenchymatous tissues that maintained normal thymic morphology. Computed tomography values were 36.72+9.48 Hu and increased by 5.56+2.62 Hu in contrast enhancement. The mean volume of the mass was 19.2 cm 3 . Twenty patients underwent positron emission tomography; among them, five (25%) showed no intake of Fluorine-18 fluorodeoxyglucose in the anterior mediastinal mass, and 15 (75%) showed radioactivity distribution in the mass with a mean standardized uptake value of 2.7; the shape was regular and radioactivity distribution was uniform. The mean follow-up duration was 40 months and all patients achieved disease-free survival. Conclusions: In the absence of pathological diagnosis, thymic regrowth following chemotherapy can be diagnosed by clinical features combined with characteristic manifestations in computed tomography and positron emission tomography scans. |
| تدمد: | 1465-3621 0368-2811 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd559ce551bf659e9e89deb8531befcTest https://doi.org/10.1093/jjco/hyq149Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8fd559ce551bf659e9e89deb8531befc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14653621 03682811 |
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