Microwave Ablation of the Atrioventricular Junction In Vivo and Ventricular Myocardium In Vitro and In Vivo. Effects of Varying Power and Duration on Lesion Volume
| العنوان: | Microwave Ablation of the Atrioventricular Junction In Vivo and Ventricular Myocardium In Vitro and In Vivo. Effects of Varying Power and Duration on Lesion Volume |
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| المؤلفون: | Yoshikazu Takahashi, Toshiaki Kojima, Akihiro Kanada, Yukio Ozawa, Yuji Kasamaki, Kazuhiko Kondo, Ichiro Watanabe, Satoshi Saito, Satoshi Kunimoto, Xinchun Yang |
| المصدر: | Japanese Heart Journal. 35:175-191 |
| بيانات النشر: | International Heart Journal (Japanese Heart Journal), 1994. |
| سنة النشر: | 1994 |
| مصطلحات موضوعية: | medicine.medical_specialty, business.industry, medicine.medical_treatment, Microwave ablation, Catheter ablation, Ventricular tachycardia, medicine.disease, Ablation, Lesion, medicine.anatomical_structure, Ventricle, Internal medicine, medicine, Cardiology, Left Ventricular Epicardium, medicine.symptom, Cardiology and Cardiovascular Medicine, Nuclear medicine, business, Endocardium |
| الوصف: | Catheter ablation in ventricular tachycardia has achieved only limited success using direct current (DC) and radiofrequency (RF) energy, due to either high complication rates or a limited lesion size. Microwave energy represents a possible alternative source of energy for percutaneous ablation of the ventricular myocardium. However, an optimal method for titration of the dose of microwave energy to achieve the desired lesion volume has not yet been established. The safety and efficacy of microwave ablation of the atrioventricular (AV) junction were studied in 11 dogs in vivo. The relationship between lesion size following microwave ablation and the power output of or exposure duration to microwave energy was also examined at disparate sites in each superfused left ventricular epicardium in vitro. To observe the pathologic changes in the myocardium after microwave ablation, microwave ablation of the endocardium of the left ventricle was carried out in 9 dogs in vivo. Complete AV block was achieved in 10 of the above 11 dogs with a mean of 5 applications of microwave energy. The lesion volume in vitro demonstrated a parallel increase with power (r=0.76) and duration (r=0.81). The mean lesion volume at 30sec was: at 10W, 0.8±1.6; 20W, 34.7±10.3; 30W, 34.7±22.4: 40W, 64.7±64.4; 50W, 87.2±42.3; 60W, 85.8±38.1; 70W, 124.7±36.5; 80W, 134.2±49.0mm3. The mean lesion volume at 80W was: at 15sec, 32.6±37.8; 30sec, 101.2±46.4; 60sec, 180.6±80.1; 120sec, 291.8±122.7; and 180sec, 459.3±204.6mm3. The ablated lesions showed discrete, homogeneous coagulation necrosis with sharp margins from the adjacent normal myocardium. Microwave energy may thus be more effective than RF energy, and have a lower risk of complications and arrythmogenesis than DC energy when used for ablation in ventricular tachycardia. |
| تدمد: | 1348-673X 0021-4868 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::4c3d6468db4752fb798431646d3f01bcTest https://doi.org/10.1536/ihj.35.175Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........4c3d6468db4752fb798431646d3f01bc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1348673X 00214868 |
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