Myocardial Infarct Size by Serum Troponin T and Myosin Light Chain 1 Concentration
| العنوان: | Myocardial Infarct Size by Serum Troponin T and Myosin Light Chain 1 Concentration |
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| المؤلفون: | Toshio Nishikimi, Kazuhide Takeuchi, Kaname Akioka, Iku Toda, Hiroyuki Yamagishi, Takashi Omura, Tomoko Tani, Masakazu Teragaki, Minoru Yoshiyama, Masahiko Takagi, Shiro Yanagi, Tadanao Takeda, Yukio Nishida |
| المصدر: | Japanese Circulation Journal. 59:154-159 |
| بيانات النشر: | Japanese Circulation Society, 1995. |
| سنة النشر: | 1995 |
| مصطلحات موضوعية: | Male, Cardiac function curve, medicine.medical_specialty, Myosin Light Chains, Myosin light-chain kinase, Physiology, Myocardial Infarction, Myosins, Scintigraphy, Troponin T, Internal medicine, medicine, Humans, cardiovascular diseases, Myocardial infarction, Aged, Ejection fraction, medicine.diagnostic_test, biology, business.industry, Anterior MI, Middle Aged, musculoskeletal system, medicine.disease, Troponin, cardiovascular system, Cardiology, biology.protein, Female, Cardiology and Cardiovascular Medicine, business, Biomarkers |
| الوصف: | The late troponin T (TnT) peak concentration, which is known to be independent of reperfusion of the infarcted zone in acute myocardial infarction (MI), has been suggested to be correlated with clinical estimates of cardiac function and myocardial infarct size. To refine the clinical application of the late TnT peak in infarct sizing, and to examine differences in this estimation in different infarct sites, we measured the serum concentrations of TnT and myosin light chain 1 (MLC1), and compared these values with left ventricular ejection fraction (LVEF) obtained from left ventriculography, and extent score (ES) and severity score (SS) obtained from 201Tl scintigraphy in patients with anterior and inferior myocardial infarction. The late TnT peak concentration was strongly correlated with the MLC1 peak value in patients with anterior MI (r = 0.67, p0.05) and in those with inferior MI (r = 0.92, p0.0005). Furthermore, there were strong linear correlations between the late TnT peak values and all of the clinical data (LVEF; r = -0.79, p0.01, ES; r = 0.75, p0.05, SS; r = 0.75, p0.05, respectively) in patients with anterior MI. However, these correlations were weak in patients with inferior MI. Similar correlations were observed between MLC1 and the clinical data. Thus, TnT and MLC1 have similar kinetics in the serum at the late phase and can be used to estimate the size of anterior infarct. |
| تدمد: | 1347-4839 0047-1828 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::157c995b6234a2de87ba8282aea51daeTest https://doi.org/10.1253/jcj.59.154Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....157c995b6234a2de87ba8282aea51dae |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13474839 00471828 |
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