التفاصيل البيبلوغرافية
| العنوان: |
Combination Antidepressant Therapy vs Monotherapy-Further Considerations. |
| المؤلفون: |
Wang, Qi, Yao, Liang, Chen, Yaolong |
| المصدر: |
JAMA Psychiatry; Aug2022, Vol. 79 Issue 8, p831-832, 2p |
| مصطلحات موضوعية: |
ANTIDEPRESSANTS, COMBINATION drug therapy, TREATMENT effectiveness, MENTAL depression, COMBINED modality therapy |
| مستخلص: |
Comment & Response B To the Editor b Henssler et al[1] conducted a systematic review and meta-analysis to investigate the treatment efficacy and tolerability of combining antidepressants vs monotherapy in adult patients with acute depression. Their meta-analysis found that combination therapy was superior to monotherapy in treatment efficacy (primary outcome standardized mean difference [SMD], 0.31; 95% CI, 0.19-0.44), and among the combinations, combining a reuptake inhibitor with an antagonist of presynaptic 2-autoreceptors (RI+ 2) was associated with better outcomes than other combinations (SMD, 0.37; 95% CI, 0.19-0.55). Based on the findings, the authors concluded that combining antidepressants seemed to be more effective than monotherapy and that RI+ 2 appeared to be the most effective combination therapy. [Extracted from the article] |
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| قاعدة البيانات: |
Supplemental Index |
