Association of Reperfusion With Brain Edema in Patients With Acute Ischemic Stroke : A Secondary Analysis of the MR CLEAN Trial
| العنوان: | Association of Reperfusion With Brain Edema in Patients With Acute Ischemic Stroke : A Secondary Analysis of the MR CLEAN Trial |
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| المؤلفون: | Kimberly, W. Taylor, Dutra, Bruna Garbugio, Boers, Anna M. M., Alves, Heitor C. B. R., Berkhemer, Olvert A., van den Berg, Lucie, Sheth, Kevin N., Roos, Yvo B. W. E. M., van der Lugt, Aad, Beenen, Ludo F. M., Dippel, Diederik W. J., van Zwam, Wim H., van Oostenbrugge, Robert J., Lingsma, Hester F., Marquering, Henk, Majoie, Charles B. L. M., Koudstaal, Peter J., van den Berg, Lucie A., Nederkoorn, Paul J., Beumer, Debbie, Staals, Julie, Boiten, Jelis, Wermer, Marieke J. H., Kappelle, L. Jaap, van Dijk, Ewoud J., Schonewille, Wouter J., Hofmeijer, Jeannette, van Oostayen, Jacques A., Vroomen, Patrick C., de Kort, Paul L. M., Keizer, Koos, de Bruijn, Sebastiaan F., van den Berg, J. S. Peter, Schreuder, Tobien H. C. M. L., Aerden, Leo A. M., Flach, H. Zwenneke, Visser, Marieke C., den Hertog, Heleen M., Brouwer, Patrick A., Emmer, Bart J., Sprengers, Marieke E. S., van den Berg, René, Nijeholt, Geert J. Lycklamaà, van Walderveen, Marianne A. A., Lo, Rob H., de Vries, Joost, Vos, Jan Albert, Eshghi, Omid, Tielbeek, Alexander V., van Dijk, Lukas C., van Hasselt, Boudewijn A. A. M., Heijboer, Roel J. J., Dallinga, René J., Bot, Joseph C. J., Gerrits, Dick G., Fransen, Puck S. S., Marquering, Henk A., Steyerberg, Ewout W., Yoo, Albert J., Jenniskens, Sjoerd F. M., van den Berg-Vos, Renske M., Karas, Giorgos B., Brown, Martin M., Liebig, Thomas, Stijnen, Theo, Andersson, Tommy, Mattle, Heinrich, Wahlgren, Nils, van der Heijden, Esther, Ghannouti, Naziha, Fleitour, Nadine, Hooijenga, Imke, Puppels, Corina, Pellikaan, Wilma, Geerling, Annet, Lindl-Velema, Annemieke, van Vemde, Gina, Klinieken, Isala, de Ridder, Ans, Greebe, Paut, de Bont-Stikkelbroeck, José, de Meris, Joke, Janssen, Kirsten, Struijk, Willy, Licher, Silvan, Boodt, Nikki, Ros, Adriaan, Venema, Esmee, Slokkers, Ilse, Ganpat, Raymie-Jayce, Mulder, Maxim, Saiedie, Nawid, Heshmatollah, Alis, Schipperen, Stefanie, Vinken, Stefan, van Boxtel, Tiemen, Koets, Jeroen |
| المساهمون: | Neurology, Radiology & Nuclear Medicine, Public Health, Radiology and nuclear medicine, VU University medical center, Amsterdam Neuroscience - Neurovascular Disorders, Beeldvorming, RS: CARIM - R3.03 - Cerebral small vessel disease, RS: CARIM - R3.11 - Imaging, MUMC+: DA BV Medisch Specialisten Radiologie (9), RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Klinische Neurowetenschappen, MUMC+: MA Neurologie (3), Radiology and Nuclear Medicine, ACS - Amsterdam Cardiovascular Sciences, ANS - Neurovascular Disorders, Graduate School, Other Research, ARD - Amsterdam Reproduction and Development, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, ACS - Microcirculation, ACS - Atherosclerosis & ischemic syndromes, ACS - Pulmonary hypertension & thrombosis |
| المصدر: | JAMA Neurology, 75(4), 453-461. American Medical Association JAMA Neurology, 75(4), 453. American Medical Association Kimberly, W T, Dutra, B G, Boers, A M M, Alves, H C B R, Berkhemer, O A, van den Berg, L, Sheth, K N, Roos, Y B W E M, van der Lugt, A, Beenen, L F M, Dippel, D W J, van Zwam, W H, van Oostenbrugge, R J, Lingsma, H F, Marquering, H, Majoie, C B L M, Koudstaal, P J, van den Berg, L A, Nederkoorn, P J, Beumer, D, Staals, J, Boiten, J, Wermer, M J H, Kappelle, L J, van Dijk, E J, Schonewille, W J, Hofmeijer, J, van Oostayen, J A, Vroomen, P C, de Kort, P L M, Keizer, K, de Bruijn, S F, van den Berg, J S P, Schreuder, T H C M L, Aerden, L A M, Flach, H Z, Visser, M C, den Hertog, H M, Brouwer, P A, Emmer, B J, Sprengers, M E S, van den Berg, R, Nijeholt, G J L, van Walderveen, M A A, Lo, R H, de Vries, J, Vos, J A, Eshghi, O, Tielbeek, A V, van Dijk, L C, van Hasselt, B A A M, Heijboer, R J J, Dallinga, R J, Bot, J C J, Gerrits, D G, Fransen, P S S, Marquering, H A, Steyerberg, E W, Yoo, A J, Jenniskens, S F M, van den Berg-Vos, R M, Karas, G B, Brown, M M, Liebig, T, Stijnen, T, Andersson, T, Mattle, H, Wahlgren, N, van der Heijden, E, Ghannouti, N, Fleitour, N, Hooijenga, I, Puppels, C, Pellikaan, W, Geerling, A, Lindl-Velema, A, van Vemde, G, Klinieken, I, de Ridder, A, Greebe, P, de Bont-Stikkelbroeck, J, de Meris, J, Janssen, K, Struijk, W, Licher, S, Boodt, N, Ros, A, Venema, E, Slokkers, I, Ganpat, R-J, Mulder, M, Saiedie, N, Heshmatollah, A, Schipperen, S, Vinken, S, van Boxtel, T & Koets, J 2018, ' Association of reperfusion with brain edema in patients with acute ischemic stroke: A secondary analysis of the MR CLEAN Trial ', JAMA Neurology, vol. 75, no. 4, pp. 453-461 . https://doi.org/10.1001/jamaneurol.2017.5162Test |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, medicine.medical_treatment, Infarction, Brain Edema, ANGIOGRAPHY, THERAPY, Cerebral edema, Brain Ischemia, 03 medical and health sciences, 0302 clinical medicine, Midline shift, Modified Rankin Scale, Internal medicine, Outcome Assessment, Health Care, medicine, INJURY, Journal Article, Humans, 030212 general & internal medicine, cardiovascular diseases, PREDICTORS, Stroke, Aged, Netherlands, Retrospective Studies, Original Investigation, THROMBOLYSIS, business.industry, Cerebral infarction, Endovascular Procedures, Odds ratio, Thrombolysis, Middle Aged, medicine.disease, MIDDLE-CEREBRAL-ARTERY, DIFFUSION, THRESHOLDS, Treatment Outcome, TISSUE, Reperfusion, Cardiology, Female, Neurology (clinical), business, INFARCTION, 030217 neurology & neurosurgery |
| الوصف: | Importance: It is uncertain whether therapeutic reperfusion with endovascular treatment yields more or less brain edema. Objective: To elucidate the association between reperfusion and brain edema. The secondary objectives were to evaluate whether brain edema could partially be responsible for worse outcomes in patients with later reperfusion or lower Alberta Stroke Program Early Computed Tomography Score. Design, Setting, and Participants: This was a post hoc analysis of the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands (MR CLEAN), which was a prospective, randomized, multicenter clinical trial of endovascular treatment compared with conventional care of patients with acute anterior circulation ischemic stroke. Of 502 patients enrolled from December 2010 to June 2014, 2 patients declined to participate. Additionally, exclusion criteria were absence of follow-up imaging or presence of parenchymal hematoma, resulting in 462 patients included in this study. Brain edema was assessed retrospectively, from December 10, 2016, to July 24, 2017, by measuring midline shift (MLS) in all available follow-up scans. Observers were blinded to clinical data. Main Outcomes and Measures: Midline shift was assessed as present or absent and as a continuous variable. Reperfusion status was assessed by the modified thrombolysis in cerebral infarction score in the endovascular treatment arm. The modified arterial occlusive lesion score was used to evaluate the recanalization status in both arms. The modified Rankin scale score at 90 days was used for functional outcome. Results: Of 462 patients, the mean (SD) age was 65 (11) years, and 41.8% (n = 193) were women. Successful reperfusion and recanalization were associated with a reduced likelihood of having MLS (adjusted common odds ratio, 0.25; 95% CI, 0.12-0.53; P |
| وصف الملف: | image/pdf |
| اللغة: | English |
| تدمد: | 2168-6149 2168-6157 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ee93941dd2c5b972bd0578fb231355Test https://hdl.handle.net/1874/377272Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c0ee93941dd2c5b972bd0578fb231355 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21686149 21686157 |
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