دورية أكاديمية
Identification of transcription complexes that contain the double bromodomain protein Brd2 and chromatin remodeling machines.
| العنوان: | Identification of transcription complexes that contain the double bromodomain protein Brd2 and chromatin remodeling machines. |
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| المؤلفون: | Denis, Gerald V, McComb, Mark E, Faller, Douglas V, Sinha, Anupama, Romesser, Paul B, Costello, Catherine E |
| المصدر: | J Proteome Res ; ISSN:1535-3893 ; Volume:5 ; Issue:3 |
| بيانات النشر: | American Chemical Society |
| سنة النشر: | 2006 |
| المجموعة: | PubMed Central (PMC) |
| الوصف: | We use affinity purification of the double bromodomain protein Brd2 to isolate a multicomponent nuclear complex from cultured cells, and apply mass spectrometry/proteomics methods to identify the participants. We then confirm by immunoblot several transcription co-activators and co-repressors, proteins of the Swi/Snf chromatin remodeling complex, which regulate transcription control of cyclin A. This multiprotein complex is likely to contribute to cell cycle control and play a role in proliferation and cancer. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1021/pr050430uTest; https://pubmed.ncbi.nlm.nih.gov/16512664Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823066Test/ |
| DOI: | 10.1021/pr050430u |
| الإتاحة: | https://doi.org/10.1021/pr050430uTest https://pubmed.ncbi.nlm.nih.gov/16512664Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823066Test/ |
| رقم الانضمام: | edsbas.7C753705 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/pr050430u |
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