دورية أكاديمية
IDH-wild-type glioblastoma cell density and infiltration distribution influence on supramarginal resection and its impact on overall survival: a mathematical model.
| العنوان: | IDH-wild-type glioblastoma cell density and infiltration distribution influence on supramarginal resection and its impact on overall survival: a mathematical model. |
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| المؤلفون: | Tripathi, Shashwat, Vivas-Buitrago, Tito, Domingo, Ricardo A, Biase, Gaetano De, Brown, Desmond, Akinduro, Oluwaseun O, Ramos-Fresnedo, Andres, Sherman, Wendy, Gupta, Vivek, Middlebrooks, Erik H, Sabsevitz, David S, Porter, Alyx B, Uhm, Joon H, Bendok, Bernard R, Parney, Ian, Meyer, Fredric B, Chaichana, Kaisorn L, Swanson, Kristin R, Quiñones-Hinojosa, Alfredo |
| المصدر: | J Neurosurg ; ISSN:1933-0693 ; Volume:136 ; Issue:6 |
| بيانات النشر: | Sheridan PubFactory |
| سنة النشر: | 2022 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | IDH–wild type, glioblastoma, mathematical model, oncology, supramarginal resection, supratotal resection |
| الوصف: | Recent studies have proposed resection of the T2 FLAIR hyperintensity beyond the T1 contrast enhancement (supramarginal resection [SMR]) for IDH-wild-type glioblastoma (GBM) to further improve patients' overall survival (OS). GBMs have significant variability in tumor cell density, distribution, and infiltration. Advanced mathematical models based on patient-specific radiographic features have provided new insights into GBM growth kinetics on two important parameters of tumor aggressiveness: proliferation rate (ρ) and diffusion rate (D). The aim of this study was to investigate OS of patients with IDH-wild-type GBM who underwent SMR based on a mathematical model of cell distribution and infiltration profile (tumor invasiveness profile). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.3171/2021.6.JNS21925Test; https://pubmed.ncbi.nlm.nih.gov/34715662Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248269Test/ |
| DOI: | 10.3171/2021.6.JNS21925 |
| الإتاحة: | https://doi.org/10.3171/2021.6.JNS21925Test https://pubmed.ncbi.nlm.nih.gov/34715662Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9248269Test/ |
| رقم الانضمام: | edsbas.90B31DD6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3171/2021.6.JNS21925 |
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