Rebound growth of BRAF mutant pediatric glioma cells after MAPKi withdrawal is associated with MAPK reactivation and secretion of microglia-recruiting cytokines.

التفاصيل البيبلوغرافية
العنوان:	Rebound growth of BRAF mutant pediatric glioma cells after MAPKi withdrawal is associated with MAPK reactivation and secretion of microglia-recruiting cytokines.
المؤلفون:	Kocher, Daniela, Cao, Lei, Guiho, Romain, Langhammer, Melanie, Lai, Yun-Lu, Becker, Pauline, Hamdi, Hiba, Friedel, Dennis, Selt, Florian, Vonhören, David, Zaman, Julia, Valinciute, Gintvile, Herter, Sonja, Picard, Daniel, Rettenmeier, Johanna, Maass, Kendra K, Pajtler, Kristian W, Remke, Marc, von Deimling, Andreas, Pusch, Stefan, Pfister, Stefan M, Oehme, Ina, Jones, David T W, Halbach, Sebastian, Brummer, Tilman, Martinez-Barbera, Juan Pedro, Witt, Olaf, Milde, Till, Sigaud, Romain
المصدر:	J Neurooncol ; ISSN:1573-7373 ; Volume:168 ; Issue:2
بيانات النشر:	Springer
سنة النشر:	2024
المجموعة:	PubMed Central (PMC)
مصطلحات موضوعية:	Cytokines, MAPK inhibitor, Pediatric low-grade glioma, Rebound growth, Treatment withdrawal, Tumor microenvironment
الوصف:	Patients with pediatric low-grade gliomas (pLGGs), the most common primary brain tumors in children, can often benefit from MAPK inhibitor (MAPKi) treatment. However, rapid tumor regrowth, also referred to as rebound growth, may occur once treatment is stopped, constituting a significant clinical challenge.
نوع الوثيقة:	article in journal/newspaper
اللغة:	English
العلاقة:	https://doi.org/10.1007/s11060-024-04672-9Test; https://pubmed.ncbi.nlm.nih.gov/38630384Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11147834Test/
DOI:	10.1007/s11060-024-04672-9
الإتاحة:	https://doi.org/10.1007/s11060-024-04672-9Test https://pubmed.ncbi.nlm.nih.gov/38630384Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11147834Test/
حقوق:	© 2024. The Author(s).
رقم الانضمام:	edsbas.A07A4D05
قاعدة البيانات:	BASE

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الوصف
DOI:	10.1007/s11060-024-04672-9