التفاصيل البيبلوغرافية
| العنوان: |
Acute pancreatitis during valproic acid administration in a patient with vascular dementia, epileptic seizures, and psychiatric symptoms: a case report |
| المؤلفون: |
Yanaga, Mako, Okamoto, Naomichi, Hashimoto, Reia, Igata, Ryohei, Konishi, Yuki, Ikenouchi, Atsuko, Isomoto, Naoki, Shinkai, Takahiro, Harada, Masaru, Yoshimura, Reiji |
| المصدر: |
J Med Case Rep |
| بيانات النشر: |
BioMed Central |
| سنة النشر: |
2023 |
| مصطلحات موضوعية: |
Case Report, socio, psy |
| الوصف: |
BACKGROUND: Valproic acid (VPA) is a relatively safe drug widely used for the treatment of epileptic seizures and mania in bipolar disorder, as well as the prevention of migraine headaches. Here, we present a case of VPA-induced pancreatitis in a patient with vascular dementia, epileptic seizures, and psychiatric symptoms. He had no distinctive abdominal symptoms. CASE PRESENTATION: A 66-year-old Japanese man was treated with VPA for agitation and violent behavior due to vascular dementia, epileptic seizures, and psychiatric symptoms. During admission, he experienced a sudden decrease in consciousness and blood pressure. Abdominal findings were unremarkable; however, blood tests showed an inflammatory response and elevated amylase levels. Contrast-enhanced abdominal computed tomography showed diffuse pancreatic enlargement and inflammation extending to the subrenal pole. VPA-induced acute pancreatitis was diagnosed, VPA was discontinued, and high-dose infusions were administered. Acute pancreatitis resolved after treatment initiation. CONCLUSIONS: Clinicians should be aware of this relatively rare side effect of VPA. Diagnosis may be challenging in elderly people and patients with dementia as they may present with non-specific symptoms. Clinicians should consider the risk of acute pancreatitis when using VPA in patients who cannot report spontaneous symptoms. Blood amylase and other parameters should be measured accordingly. |
| نوع الوثيقة: |
text |
| اللغة: |
English |
| العلاقة: |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226237Test/ |
| الإتاحة: |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226237Test/ |
| حقوق: |
undefined |
| رقم الانضمام: |
edsbas.3DFC963 |
| قاعدة البيانات: |
BASE |
