دورية أكاديمية
Type 2 diabetes exacerbates changes in blood pressure-independent arterial stiffness: cross-sectional and longitudinal evidence from the SUMMIT study.
| العنوان: | Type 2 diabetes exacerbates changes in blood pressure-independent arterial stiffness: cross-sectional and longitudinal evidence from the SUMMIT study. |
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| المؤلفون: | Aizawa, Kunihiko, Gates, Phillip E, Mawson, David M, Casanova, Francesco, Gooding, Kim M, Hope, Suzy V, Goncalves, Isabel, Nilsson, Jan, Khan, Faisel, Colhoun, Helen M, Natali, Andrea, Palombo, Carlo, Shore, Angela C |
| المصدر: | J Appl Physiol (1985) ; ISSN:1522-1601 ; Volume:136 ; Issue:1 |
| بيانات النشر: | Atypon |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | aging, aorta, blood pressure, ultrasound |
| الوصف: | Greater central artery stiffness is observed in people with type 2 diabetes (T2DM). Elevated blood pressure (BP) and altered arterial wall structure/composition in T2DM are generally considered as main drivers for this alteration. However, because conventional arterial stiffness measures are BP-dependent and as such an influence of BP remains in a measure, it is unclear if greater central artery stiffness is a function of greater BP, or due to changes in the structure and composition of the arterial wall. We aimed to measure BP-independent arterial stiffness (β0) cross-sectionally and longitudinally in T2DM. We studied 753 adults with T2DM (DM+) and 436 adults without (DM-) at baseline (Phase 1), and 310 DM+ and 210 DM- adults at 3-yr follow-up (Phase 2). We measured carotid-femoral pulse wave velocity and used it to calculate β0. In Phase 1, β0 was significantly greater in DM+ than DM- after adjusting for age and sex [27.5 (26.6-28.3) vs. 23.6 (22.4-24.8) au, P < 0.001]. Partial correlation analyses after controlling for age and sex showed that β0 was significantly associated with hemoglobin A1c (r = 0.15 P < 0.001) and heart rate [(HR): r = 0.23 P < 0.001)] in DM+. In Phase 2, percentage-change in β0 was significantly greater in DM+ than DM- [19.5 (14.9-24.0) vs. 5.0 (-0.6 to 10.6) %, P < 0.001] after adjusting for age, sex, and baseline β0. β0 was greater in DM+ than DM- and increased much more in DM+ than in DM- over 3 yr. This suggests that T2DM exacerbates BP-independent arterial stiffness and may have a complemental utility to existing arterial stiffness indices.NEW & NOTEWORTHY We demonstrate in this study a greater BP-independent arterial stiffness β0 in people with type 2 diabetes (T2DM) compared to those without, and also a greater change in β0 over 3 yr in people with T2DM than those without. These findings suggest that the intrinsic properties of the arterial wall may change in a different and more detrimental way in people with T2DM and likely represents accumulation of cardiovascular risk. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1152/japplphysiol.00283.2023Test; https://pubmed.ncbi.nlm.nih.gov/37969084Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11208039Test/ |
| DOI: | 10.1152/japplphysiol.00283.2023 |
| الإتاحة: | https://doi.org/10.1152/japplphysiol.00283.2023Test https://pubmed.ncbi.nlm.nih.gov/37969084Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11208039Test/ |
| رقم الانضمام: | edsbas.10CAF19A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1152/japplphysiol.00283.2023 |
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