المؤلفون: Yari, Zahra¹, Mirmiran, Parvin² mirmiran@endocrine.ac.ir

المصدر: Iranian Journal of Kidney Diseases. Jul2018, Vol. 12 Issue 4, p204-208. 5p.

مصطلحات موضوعية: *KIDNEY disease treatments, *ALKALINITY, *DIET therapy, *CHRONIC disease treatment, *ACIDOSIS

مستخلص: Chronic kidney disease is defined as a glomerular filtration rate lower than 60 mL/min/1.73 m2, which is regarded as a public health priority and part of the growing burden of noncommunicable diseases. Reduced kidney function is concomitant with high levels of inflammatory factors, abnormal lipid profile, and anemia, as well as bone abnormalities, calcium deposition outside the bones, endothelial dysfunction, and cardiomyopathy. Furthermore, metabolic acidosis is a common complication in chronic kidney disease that is associated with secondary hyperparathyroidism and faster kidney disease progression. Effective preventive approaches may slow progression of chronic kidney disease and reduce the risk of subsequent morbidity and mortality. It seems that correction of metabolic acidosis slows down the decline in glomerular filtration rate and is one of the noble approaches. A diet rich in fruits and vegetables instead of bicarbonate therapy is feasible and economical and appears to have a positive effect on kidney hemodynamic function. [ABSTRACT FROM AUTHOR]

المؤلفون: Movahedian, Mina¹, Tabibi, Hadi² hadtabibi@yahoo.com, Atabak, Shahnaz³, Hedayati, Mehdi⁴, Rahmani, Leila⁵, Yari, Zahra¹

المصدر: Iranian Journal of Kidney Diseases. Mar2021, Vol. 1 Issue 2, p134-142. 9p.

مصطلحات موضوعية: *BLOOD pressure, *PERITONEAL dialysis, *HEMODIALYSIS patients, *SYSTOLIC blood pressure, *ISOFLAVONES, *RESEARCH, *RESEARCH methodology, *BLOOD sugar, *MEDICAL cooperation, *EVALUATION research, *COMPARATIVE studies, *RANDOMIZED controlled trials, *BLIND experiment

مستخلص: Introduction: High serum concentrations of glucose, advanced glycation end products (AGEs), and hypertension are some of the major risk factors for cardiovascular disease and peritoneal membrane fibrosis in peritoneal dialysis (PD) patients. Some investigations in nonuremic individuals have indicated that isoflavones can reduce serum glucose, blood pressure, and increase insulin sensitivity. However, such study in this field in PD patients is still lacking. Therefore, we aimed to determine the effects of isoflavones on serum glucose, fructosamine, AGEs, and blood pressure in PD patients.Methods: This study was a randomized, double blind, placebocontrolled trial. Thirty-eight PD patients were randomly assigned to either the isoflavone group or the placebo. The patients in the isoflavone group received 100 mg/d soy isoflavone for 8 weeks, while the control group received corresponding placebo. At baseline and the end of the 8th week, 7 mL of blood was collected from each patient and serum glucose, fructosamine, carboxymethyl lysine, pentosidine, accompanied by systolic and diastolic blood pressures were measured.Results: Serum glucose and pentosidine reduced significantly in the isoflavone group at the end of 8th week compared with baseline (P < .05), whereas no statistically significant changes were observed in the placebo group. Serum carboxymethyl lysine, fructosamine, and systolic and diastolic blood pressures did not significantly change within each group during the study.Conclusion: This study indicates that soy isoflavones could decrease serum glucose and pentosidine in PD patients. [ABSTRACT FROM AUTHOR]