دورية أكاديمية
Long-term clinical and real-world experience with Crohn’s disease treated with anti-tumor necrosis factor-α antibodies
| العنوان: | Long-term clinical and real-world experience with Crohn’s disease treated with anti-tumor necrosis factor-α antibodies |
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| المؤلفون: | Haruka Otake, Satohiro Matsumoto, Hirosato Mashima |
| المصدر: | Intestinal Research, Vol 20, Iss 4, Pp 464-474 (2022) |
| بيانات النشر: | Korean Association for the Study of Intestinal Diseases, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine LCC:Diseases of the digestive system. Gastroenterology |
| مصطلحات موضوعية: | crohn disease, infliximab, adalimumab, loss of response, c-reactive protein to albumin ratio, Medicine, Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: | Background/Aims Although anti-tumor necrosis factor (TNF)-α agents are important therapeutic drugs for Crohn’s disease (CD), data regarding their long-term sustained effects are limited. Herein, we evaluated the long-term loss of response (LOR) to anti-TNF-α agents in patients with CD. Methods This retrospective study included patients with CD who started treatment with infliximab or adalimumab as a first-line therapeutic approach. The cumulative event-free, retention, and surgery-free rates after the start of biological therapy were analyzed. Secondary LOR was analyzed in patients who achieved corticosteroid-free clinical remission after the start of biological therapy. Cox proportional hazards models were used to analyze the predictive factors of secondary LOR. Results The cumulative event-free rates at 1, 2, 5, and 10 years were 83.3%, 75.1%, 37.4%, and 23.3%, respectively. The incidence of LOR was 10.6% per patient-year of follow-up. At 12–14 weeks after the start of biological therapy, the proportion of patients with a C-reactive protein to albumin (CRP/ALB) ratio ≥0.18 was significantly higher in patients with LOR (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1598-9100 2288-1956 |
| العلاقة: | http://irjournal.org/upload/pdf/ir-2021-00139.pdfTest; https://doaj.org/toc/1598-9100Test; https://doaj.org/toc/2288-1956Test |
| DOI: | 10.5217/ir.2021.00139 |
| الوصول الحر: | https://doaj.org/article/408c37a7990a46eb8a9ab75915b8817cTest |
| رقم الانضمام: | edsdoj.408c37a7990a46eb8a9ab75915b8817c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15989100 22881956 |
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| DOI: | 10.5217/ir.2021.00139 |