التفاصيل البيبلوغرافية
| العنوان: |
Achieving Antigen-Specific Tolerance in Diabetes: Regulating Specifically. |
| المؤلفون: |
Chen, Wei, Bluestone, Jeffrey A., Herold, Kevan C. |
| المصدر: |
International Reviews of Immunology; Sep-Dec2005, Vol. 24 Issue 5/6, p287-305, 19p, 1 Diagram |
| مصطلحات موضوعية: |
CELLULAR mechanics, DIABETES, LYMPHOCYTES, T cells, IMMUNOGLOBULINS, IMMUNE response, IMMUNOLOGY, ENDOCRINE diseases, LYMPHOID tissue |
| مستخلص: |
Autoreactive T cells that escape negative selection in the thymus do not normally cause productive immune responses to self-antigens because of a number of regulatory mechanisms. Studies with anti-CD3 monoclonal antibodies (mAbs) have suggested that immune regulatory mechanisms are induced by drug treatments that are able to stop on-going unwanted immune responses, such as type 1 diabetes, involving induction of regulatory T cells. TGF-β dependent and independent mechanisms have been described involving CD4 + as well as CD8 + T cells. The challenge is now to apply these mechanisms in an antigen-specific manner and so that lasting tolerance to the autoimmune responses can be maintained. We discuss recent data concerning the mechanisms of anti-CD3 mAb treatment and the ways in which our understanding of these mechanisms can be used to develop adoptive immune therapy with regulatory T cells to treat patients with type 1 diabetes or other autoimmune diseases. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
