Assessment of CD-105 as an Angiogenic Modulator in Odontogenic Myxomas and Dental Follicles
| العنوان: | Assessment of CD-105 as an Angiogenic Modulator in Odontogenic Myxomas and Dental Follicles |
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| المؤلفون: | José Manuel Aguirre-Urizar, J. Eduardo Farfán-Morales, Maria Luisa Gainza-Cirauqui, Xabier Marichalar-Mendia, Adalberto Mosqueda-Taylor, Ronell Bologna-Molina, María del Carmen González-Galván |
| المصدر: | COLIBRI Universidad de la República instacron:Universidad de la República |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, Pathology, medicine.medical_specialty, Adolescent, Angiogenesis, Odontogenic Tumors, Odontogenic myxoma, Pathology and Forensic Medicine, 03 medical and health sciences, Young Adult, 0302 clinical medicine, medicine, Biomarkers, Tumor, Neoplasm, Humans, cardiovascular diseases, Child, Dental follicle, Neovascularization, Pathologic, business.industry, Mouth -- Diseases -- Diagnosis, Microvascular Density, Endoglin, Myxoma, Dental Sac, 030206 dentistry, medicine.disease, Odontogenic tumors -- Histopathology, 030220 oncology & carcinogenesis, cardiovascular system, Immunohistochemistry, Surgery, Angiogenesis Inducing Agents, Female, Anatomy, business, Teeth -- Diseases -- Diagnosis |
| الوصف: | Aim. Odontogenic myxoma is a benign intraosseous neoplasm of the jaws, with a locally aggressive behavior and a high recurrence rate. CD-105 is a homodimeric cell membrane glycoprotein and is a component of the TGF-β1 growth factor receptor complex that modulates angiogenesis by regulating the proliferation, differentiation and cellular migration. The aim of this study is to quantify the microvascular density of the odontogenic myxoma based on the expression of CD-105. Materials and Methods. The analysis included 18 odontogenic myxoma and 18 dental follicles as controls. A standard immunohistochemical procedure was performed with the CD-105 antibody. Five representative fields (40×) of the odontogenic myxoma and the dental follicles were selected to determine the microvascular density, which was then followed by a descriptive and comparative statistical analysis. Results. Dental follicles presented a significantly higher microvascular density compared with odontogenic myxoma (P = .001). The odontogenic myxoma smaller than 3 cm showed a greater microvascular density than those larger than 3 cm in size (P > .05), and the microvascular density was lower in large odontogenic myxomas as compared with the dental follicles (P = .003). Conclusion. A weaker expression of CD-105 in odontogenic myxoma might indicate a lower angiogenic activity, suggesting that vascular proliferation has a limited role in the growth mechanisms and in the aggressive behavior of this neoplasm. peer-reviewed |
| وصف الملف: | application/pdf |
| تدمد: | 1940-2465 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8605dc396aaf78457766b7bf0750e16eTest https://pubmed.ncbi.nlm.nih.gov/26888956Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8605dc396aaf78457766b7bf0750e16e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19402465 |
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