التفاصيل البيبلوغرافية
| العنوان: |
Post-stroke fatigue is associated with resting state posterior hypoactivity and prefrontal hyperactivity. |
| المؤلفون: |
Cotter, Georgia, Salah Khlif, Mohamed, Bird, Laura, E Howard, Mark, Brodtmann, Amy, Egorova-Brumley, Natalia |
| المصدر: |
International Journal of Stroke; Oct2022, Vol. 17 Issue 8, p906-913, 8p |
| مصطلحات موضوعية: |
FATIGUE (Physiology), FUNCTIONAL magnetic resonance imaging, HYPOKINESIA, EXECUTIVE function |
| مستخلص: |
Background: Fatigue is associated with poor functional outcomes and increased mortality following stroke. Survivors identify fatigue as one of their key unmet needs. Despite the growing body of research into post-stroke fatigue, the specific neural mechanisms remain largely unknown. Aim: This observational study aimed to identify resting state brain activity markers of post-stroke fatigue. Method: Sixty-three stroke survivors (22 women; age 30–89 years; mean 67.5 ± 13.4 years) from the Cognition And Neocortical Volume After Stroke study, a cohort study examining cognition, mood, and brain volume in stroke survivors following ischemic stroke, underwent brain imaging three months post-stroke, including a 7-minute resting state functional magnetic resonance imaging. We calculated the fractional amplitude of low-frequency fluctuations, which is measured at the whole-brain level and can detect altered spontaneous neural activity of specific regions. Results: Forty-five participants reported experiencing post-stroke fatigue as measured by an item on the Patient Health Questionnaire-9. Fatigued compared to non-fatigued participants demonstrated significantly lower resting-state activity in the calcarine cortex (p < 0.001, cluster-corrected pFDR = 0.009, k = 63) and lingual gyrus (p < 0.001, cluster-corrected pFDR = 0.025, k = 42) and significantly higher activity in the medial prefrontal cortex (p < 0.001, cluster-corrected pFDR = 0.03, k = 45). Conclusions: Post-stroke fatigue is associated with posterior hypoactivity and prefrontal hyperactivity reflecting dysfunction within large-scale brain systems such as fronto-striatal-thalamic and frontal-occipital networks. These systems in turn might reflect a relationship between post-stroke fatigue and abnormalities in executive and visual functioning. This whole-brain resting-state study provides new targets for further investigation of post-stroke fatigue beyond the lesion approach. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
