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1
المؤلفون: Gustavo E. A. Brito-Melo, Fabiano T. Amorim, Mariana Aguiar de Matos, Etel Rocha-Vieira, Rosalina Tossige-Gomes, Karine Beatriz Costa, Flávio de Castro Magalhães, Elizabethe Adriana Esteves, Vinícius de Oliveira Ottone
المصدر: International journal of sports medicine. 40(3)
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Neutrophils, Phagocytosis, Priming (immunology), Physical Therapy, Sports Therapy and Rehabilitation, Inflammation, 030204 cardiovascular system & hematology, High-Intensity Interval Training, Superoxide dismutase, 03 medical and health sciences, chemistry.chemical_compound, Young Adult, 0302 clinical medicine, Internal medicine, Lactate dehydrogenase, medicine, Humans, Orthopedics and Sports Medicine, Receptor, Muscle, Skeletal, chemistry.chemical_classification, Reactive oxygen species, biology, L-Lactate Dehydrogenase, business.industry, Interleukin-8, Skeletal muscle, 030229 sport sciences, Endocrinology, medicine.anatomical_structure, chemistry, biology.protein, Cytokines, medicine.symptom, business, Reactive Oxygen Species, Oxidation-Reduction
الوصف: This study evaluated the effect of an acute high-intensity interval exercise (HIIE) session on the function of human neutrophils. Twelve sedentary men performed a HIIE session (8 bouts of 60 s at 90% of peak power, intercalated with 75 s of active recovery at 30 W). Neutrophils were collected before, 30 min and 24 h after the exercise session for the evaluation of phagocytic capacity, expression of phagocytic receptors, reactive oxygen species generation, and redox status. 24 h after the HIIE session, an increase was observed in both neutrophil phagocytic capacity and yeast-induced generation of reactive oxygen species, which indicates neutrophil priming in response to an acute HIIE session. Neutrophils also presented an increase in superoxide dismutase activity 24 h after the exercise. Improvement in neutrophil function was accompanied by increased serum levels of IL-8 and increased concentration of plasma lactate dehydrogenase. Our findings show a late activating effect of one HIIE session on neutrophils. We propose that priming of neutrophils by HIIE may play a role in skeletal muscle inflammation after exercise.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb3275951655209a4317cace62d7b974Test
https://pubmed.ncbi.nlm.nih.gov/30703845Test -
2
المؤلفون: Debora Di Mauro, Riccardo Ientile, Davide Barreca, Mercurio Vecchio, Daniela Caccamo, Fabio Trimarchi, Giuseppina Rizzo, Monica Currò, Giuseppa Visalli
المصدر: International journal of sports medicine. 39(5)
مصطلحات موضوعية: Male, Homocysteine, Physical Therapy, 030204 cardiovascular system & hematology, Reductase, medicine.disease_cause, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, Orthopedics and Sports Medicine, Creatine Kinase, PON1 polymorphisms, Water Sports, biology, Water polo, Skeletal, Single Nucleotide, PON1, Advanced Oxidation Protein Products, Cardiovascular Diseases, 030220 oncology & carcinogenesis, Muscle, MTHFR gene variants, Adult, Hyperhomocysteinemia, medicine.medical_specialty, Genotype, Physical Therapy, Sports Therapy and Rehabilitation, Sports Therapy and Rehabilitation, Polymorphism, Single Nucleotide, 03 medical and health sciences, Young Adult, Internal medicine, medicine, Humans, Polymorphism, Muscle, Skeletal, Methylenetetrahydrofolate Reductase (NADPH2), L-Lactate Dehydrogenase, business.industry, Aryldialkylphosphatase, Paraoxonase, medicine.disease, Cardiovascular disease risk, Oxidative Stress, Endocrinology, chemistry, Methylenetetrahydrofolate reductase, biology.protein, Creatine kinase, business, Oxidative stress, advanced oxidation protein products, homocysteine
الوصف: Methylene-tetrahydrofolate reductase (MTHFR) and paraoxonase 1 (PON1) gene polymorphisms have been associated with hyperhomocysteinemia and oxidative stress increase, that are established cardiovascular risk factors. Given that intense physical activity may increase the susceptibility to adverse cardiovascular outcomes, here we investigated the effects of MTHFR C677T and A1298C as well as PON1 Q192R gene polymorphisms on cardiovascular risk markers in twenty-eight male water polo elite players. The mean plasma levels of homocysteine (Hcy) and advanced oxidation protein products (AOPP) were above reference limits in resting conditions, and increased after competition. Moreover, a positive correlation was found between Hcy and AOPP concentrations, and also between their variations (ratio post-exercise/pre-exercise values) and the variations of lactic dehydrogenase (LDH) and creatine kinase (CK) activities, known as muscle damage markers. The highest Hcy and AOPP values were found in subjects having either MTHFR CT/AC or TT/AA, and PON1 QR192 genotype, respectively. After exercise, Hcy concentrations significantly increased in CT/AC or TT/AA subjects than in athletes having other MTHFR genotypes. A training-induced increase in plasma levels of LDH and CK activities, as well as myoglobin concentrations, was also observed, even if significant differences were found only for CK activity in athletes with MTHFR CT/AC or TT/AA athletes.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a642af0b1ce771cef7b6f43efd882f7Test
https://pubmed.ncbi.nlm.nih.gov/29564841Test -
3
المؤلفون: Ross Tucker, Kathryn H. Myburgh, Jordan Santos-Concejero, Tertius Abraham Kohn, Birgitta Essén-Gustavsson
المصدر: International Journal of Sports Medicine. 35:809-816
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Black People, Physical Therapy, Sports Therapy and Rehabilitation, White People, Running, Young Adult, chemistry.chemical_compound, Oxygen Consumption, Heart Rate, Internal medicine, Lactate dehydrogenase, Heart rate, medicine, Humans, Orthopedics and Sports Medicine, Lactic Acid, Treadmill, Respiratory system, Hypoxia, Muscle, Skeletal, Fatigue, Lactate concentration, Anthropometry, Myosin Heavy Chains, business.industry, Respiration, Performance impairment, Hypoxia (medical), Oxygen, Endocrinology, chemistry, Exercise Test, Physical Endurance, Physical therapy, medicine.symptom, Maximal exercise, business, human activities
الوصف: This study aimed to compare the response of performance-matched black and white runners during maximal and sub-maximal running in normoxic and hypoxic conditions. 14 well-trained runners (8 black, 6 white) performed 2 incremental maximal exercise tests and 2 fatigue resistance tests at 21% O2 (normoxia) or 14% O2 (hypoxia). Respiratory parameters, heart rate (HR), lactate concentration ([La-]) as well as arterial saturation (SpO2) were measured. Enzyme activities and myosin heavy chain content (MHC) were also measured. White runners reached a significantly greater peak treadmill speed and a higher HRmax than black runners in hypoxia (p
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bc69f9eca02d1f9f442cd4a9b432507Test
https://doi.org/10.1055/s-0034-1367012Test -
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المؤلفون: Esperanza Ortega, Pilar Aranda, V.A. Aparicio, Mohamed Tassi, Elena Nebot, Daniel Camiletti-Moirón, Jesús M. Porres
المصدر: International Journal of Sports Medicine. 35:639-644
مصطلحات موضوعية: Male, medicine.medical_specialty, Nitrogen, Urinary system, Physical Therapy, Sports Therapy and Rehabilitation, Urine, Kidney, Eating, Random Allocation, chemistry.chemical_compound, Stress, Physiological, Physical Conditioning, Animal, Internal medicine, Lactate dehydrogenase, medicine, Animals, Urea, Testosterone, Orthopedics and Sports Medicine, Rats, Wistar, Muscle, Skeletal, Creatine Kinase, Creatinine, biology, business.industry, Body Weight, Albumin, Resistance Training, Organ Size, medicine.disease, medicine.anatomical_structure, Endocrinology, chemistry, biology.protein, Creatine kinase, Corticosterone, business, Biomarkers, Kidney disease
الوصف: We investigated the renal effects of a high-intensity exercise (HIE) program based on strength training. 20 Wistar rats were randomly assigned to 2 experimental groups performing HIE or control over 12 weeks. Urinary volume, pH, citrate and calcium, and plasma urea, total proteins, creatinine, albumin, lactate dehydrogenase, creatine kinase (CK), calcium, magnesium, corticosterone and testosterone were measured. We also studied renal morphology with the Fibrosis HR® software. Plasma urea and CK concentrations were higher in the HIE compared to the control group (p
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ccd6ba1359770170c1944715f629a02Test
https://doi.org/10.1055/s-0033-1354383Test -
5
المصدر: International Journal of Sports Medicine. 25:99-102
مصطلحات موضوعية: Male, medicine.medical_specialty, medicine.drug_class, Physical Therapy, Sports Therapy and Rehabilitation, Glucosephosphate Dehydrogenase, Biology, Testicle, chemistry.chemical_compound, Physical Conditioning, Animal, Internal medicine, Lactate dehydrogenase, Testis, Male rats, medicine, Animals, Glucose-6-phosphate dehydrogenase, Testosterone, Orthopedics and Sports Medicine, Rats, Wistar, chemistry.chemical_classification, L-Lactate Dehydrogenase, Androgen, Continuous training, Rats, Succinate Dehydrogenase, Enzyme, Endocrinology, medicine.anatomical_structure, chemistry
الوصف: To gain more information on the effects of training types on testosterone secretion, the present study investigated the relationship between serum testosterone (ST) and the activities of oxydoreductive enzymes in Leydig cells to continuous and intermittent training regimes. Male rats swam with a load of 3.5 % body weight for 90 min in the continuous training group, and 15 min separated by a 7-min rest interval x 6 times in the intermittent training group, 6 days per week for 5 weeks. ST were measured immediately and 24 h after exercise, and the activities of SDH, LDH and G6PDH in Leydig cells were measured 24 h after exercise, following 5 weeks of training. It was found that ST declined following continuous (0.54 +/- 0.32 nmol/l) and intermittent (1.64 +/- 1.80 nmol/l) exercise compared to sedentary group (9.55 +/- 5.17 nmol/l). This diminishing effect on ST was still significant 24 h after continuous exercise (5.96 +/- 2.79 nmol/l), not after intermittent exercise (7.41 +/- 4.77 nmol/l). The activities of SDH and LDH increased, whereas G6PDH decreased in Leydig cells, after both continuous and intermittent training. SDH and G6PDH showed the high activities in the intermittent training group relative to continuous training group. These differences in the activities of SDH and G6PDH might be considered as the possible causes for ST responses to training types.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c309833632c8c098d35318977455a27Test
https://doi.org/10.1055/s-2004-819950Test -
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المؤلفون: Chorng Kuang How, Y.-T. S. Shiau, Sen Kuang Hou, Carlos Lam, Wei Fong Kao, L.-H. Li, Yu Hui Chiu, Ray Jade Chen, S.-L. Chou, Chen Chang Yang
المصدر: International Journal of Sports Medicine. 34:841-845
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Physical Therapy, Sports Therapy and Rehabilitation, medicine.disease_cause, Running, Young Adult, chemistry.chemical_compound, Liver Function Tests, Lactate dehydrogenase, Internal medicine, medicine, Humans, Orthopedics and Sports Medicine, Inflammation, Hepatitis B virus, biology, medicine.diagnostic_test, business.industry, Case-control study, Middle Aged, Hepatitis B, medicine.disease, Oxidative Stress, Endocrinology, Liver, chemistry, Case-Control Studies, Carrier State, DNA, Viral, Immunology, Physical Endurance, biology.protein, Cytokines, Female, Creatine kinase, Liver function, business, Liver function tests, human activities, Biomarkers, Oxidative stress
الوصف: This study compares the serological markers between runners who are hepatitis B virus carries (HBVc) and runners who are non-HBVc in a 100-km ultra-marathon race. Blood samples of 8 HBVc and 18 non-HBVc runners were drawn 1 week before, immediately following, and 24 h after the race. Samples were analyzed and compared between the 2 groups for liver function tests, muscle damage markers and oxidative stress cytokines. For HBVc runners, HBV-DNA (hepatitis B virus-deoxyribonucleic acid) levels were also evaluated for virus reactivation. The results demonstrate a statistically significant increase in both immediate and 24-h post-race values for alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), creatine kinase (CK), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), compared with pre-race values. No statistically significant difference was observed between the 2 groups for the values of AST, LDH, CK, hs-CRP, IL-6 and TNF-α either before or after the race. There was also no statistically significant change in the levels of HBV-DNA in HBVc runners. These findings suggest that HBVc runners do not have higher risks of liver function impairment, muscle breakdown and inflammatory response compared to non-HBVc runners in such endurance races.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b33a9172a50e1dfcac2dea0d92a0ec83Test
https://doi.org/10.1055/s-0032-1331769Test -
7
المؤلفون: Yoshihiko Yamazaki, A. Wakayama, T. Ohkuwa, T. Shimoda, Yasutake Sato, S. Tamura, Miharu Miyamura, T. Yamamoto, Hiroshi Itoh
المصدر: International Journal of Sports Medicine. 21:369-374
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Free Radicals, Thiobarbituric acid, medicine.medical_treatment, Physical Therapy, Sports Therapy and Rehabilitation, Running, Lipid peroxidation, chemistry.chemical_compound, Heart Rate, Internal medicine, Lactate dehydrogenase, Heart rate, medicine, Humans, Vitamin E, Orthopedics and Sports Medicine, Muscle, Skeletal, Creatine Kinase, L-Lactate Dehydrogenase, biology, Chemistry, VO2 max, Endocrinology, Blood chemistry, Biochemistry, Dietary Supplements, biology.protein, Creatine kinase, Lipid Peroxidation
الوصف: The purpose of this study was to examine whether vitamin E supplementation in humans would attenuate an increase of serum enzymes as an indirect marker of muscle damage following a sudden large increase in the running distance in a 6-day running training or not. A randomized and placebo-controlled study was carried out on fourteen male runners who were supplied vitamin E (alpha-tocopherol 1200 IU x day(-1); E) or placebo (P) 4 weeks prior to (T1) and during 6 successive days of running training (48.3 +/- 5.7 km x day(-1), means +/- SD). Resting venous blood samples were obtained before maximal treadmill running, at T1, the day immediately before (T2), the next day (T3), and three weeks (T4) after the running training. Serum levels of alpha-tocopherol, lipid peroxidation products (thiobarbituric acid; TBA), creatine kinase (CK), lactate dehydrogenase (LDH), and LDH isozyme 1-5 were quantitatively analyzed. No significant difference was found in maximal oxygen uptake (VO2max) and maximal heart rates following the exhaustive exercise between the P and E group during the experiments. Vitamin E supplementation significantly increased serum alpha-tocopherol (p
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8a4c4520afcfed24b09398eeaac35fbTest
https://doi.org/10.1055/s-2000-3777Test -
8
المصدر: International Journal of Sports Medicine. 27:60-66
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Vastus lateralis muscle, Physical Therapy, Sports Therapy and Rehabilitation, Physical exercise, Incremental exercise, chemistry.chemical_compound, Oxygen Consumption, Internal medicine, Lactate dehydrogenase, medicine, Humans, Citrate synthase, Orthopedics and Sports Medicine, Lactic Acid, Exercise, biology, VO2 max, Surgery, Lactic acid, Endocrinology, chemistry, Physical Endurance, biology.protein, Female, Phosphofructokinase
الوصف: The purpose of the present study was to relate the training-induced alterations in lactate kinetics parameters to the concomitant changes in time to exhaustion (T(lim)) at a work rate corresponding to maximal oxygen uptake (Pa(peak)). Eight subjects performed before and after training i) an incremental exercise up to exhaustion to determine Pa(peak), ii) a 5-min 90 % Pa(peak) exercise followed by a 90-min passive recovery to determine an individual blood lactate recovery curve fitted to the bi-exponential time function: La(t) = La(0) + A1(1 - e -gamma1 x t) + A2(1 - e -gamma2 x t), and iii) a time to exhaustion at Pa peak to determine T lim. A biopsy of the vastus lateralis muscle was made before and after training. The training programme consisted in pedalling on a cycle ergometer 2 h a day, 6 days a week, for 4 weeks. Training-induced increases (p < 0.05) in Pa(peak), muscle capillary density, citrate synthase activity, gamma2 that denotes the lactate removal ability (from 0.0547 +/- 0.0038 to 0.0822 +/- 0.0071 min (-1)) and T(lim) (from 299 +/- 23 to 486 +/- 63 s), decreases (p < 0.05) in activities of lactate dehydrogenase (LDH) and muscle type of LDH, the phosphofructokinase/citrate synthase activities ratio and the estimated net amount of lactate released (NALR) during exercise recovery (from 66.5 +/- 8.6 to 47.2 +/- 11.1 mmol) were also observed. The improvement of T (lim) with training was related to the increase in gamma2 (r = 0.74, p = 0.0367) and to the decrease in NALR (r = 0.77, p = 0.0250). These results suggest that the post-training greater ability to remove lactate from the organism and reduced muscle lactate accumulation during exercise account for the concomitant improvement of the time to exhaustion during high-intensity exercise performed at the same relative work rate.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1114041da7838163bf71c9dd4c31a08bTest
https://doi.org/10.1055/s-2005-837507Test -
9
المؤلفون: Foued Salmen Espindola, Miguel M. Díaz, Olga L. Bocanegra, Silvio S. Soares, Renata Roland Teixeira
المصدر: International journal of sports medicine. 34(1)
مصطلحات موضوعية: Male, medicine.medical_specialty, Saliva, Hemodynamics, Physical Therapy, Sports Therapy and Rehabilitation, Nitric Oxide, Nitric oxide, chemistry.chemical_compound, Young Adult, Internal medicine, Lactate dehydrogenase, Health Sciences, medicine, Humans, Orthopedics and Sports Medicine, Creatine Kinase, Swimming, biology, L-Lactate Dehydrogenase, business.industry, Venous blood, gamma-Glutamyltransferase, Hälsovetenskaper, Endocrinology, chemistry, Athletes, Salivary alpha-Amylases, biology.protein, Biomarker (medicine), Creatine kinase, business, Biomarkers, Biomedical sciences
الوصف: This study examined the variation in salivary nitric oxide (NO), alpha-amylase (sAA) and serum markers of muscle injury during 21 weeks of training in elite swimmers. Samples of saliva and blood were collected once a month during 5 months from 11 male professional athletes during their regular training season. The variation in each marker throughout the 21 weeks was compared with the dynamics of training volume, intensity and load. Unstimulated whole saliva was assessed for NO and sAA whereas venous blood was assessed for lactate dehydrogenase, creatine kinase, and γ-glutamyltransferase. Nitric oxide and sAA showed a proportional response to the intensity of training. However, whereas the concentration of NO increased across the 21 weeks, the activity of sAA decreased. Similar variations in the concentration of NO and the markers of muscle injury were also observed. The higher concentration of NO might be attributed to changes in haemodynamics and muscle regenerative processes. On the other hand, autonomic regulation towards parasympathetic predominance might have been responsible for the decrease in sAA activity. These findings provide appealing evidence for the utilization of salivary constituents in sports medicine to monitor training programmes.
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c331c70dd2cee7b5c1f5a686092a3b99Test
https://pubmed.ncbi.nlm.nih.gov/22960992Test -
10
المؤلفون: Kazunori Nosaka, Priscilla M. Clarkson
المصدر: International Journal of Sports Medicine. 17:120-127
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Movement, Elbow, Aspartate transaminase, Physical Therapy, Sports Therapy and Rehabilitation, Isometric exercise, chemistry.chemical_compound, Internal medicine, Lactate dehydrogenase, Elbow Joint, medicine, Humans, Eccentric, Orthopedics and Sports Medicine, Muscle, Skeletal, Creatine Kinase, biology, Myoglobin, business.industry, Blood Proteins, Anatomy, Magnetic Resonance Imaging, medicine.anatomical_structure, Endocrinology, chemistry, biology.protein, Creatine kinase, medicine.symptom, business, Muscle contraction
الوصف: There is a large inter-subject variability in serum creatine kinase (CK) response after eccentric exercise. This study examined and compared the variability of CK activity, other serum protein increases (aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, aldolase, myoglobin),changes in muscle damage indicators (maximal isometric force: MIF, relaxed and flexed elbow joint angle: RANG and FANG, circumference: CIR, and muscle soreness level: SOR), and changes in magnetic resonance (MR) images. Ten male subjects (21.7 +/- 1.6 yrs) performed 24 maximal eccentric actions of the elbow flexors, and measurements except MR images were taken immediately before and after, and for 10 days after exercise. MR images were taken 7 days after exercise. A large variability in peak CK response (236 - 25,244 IU.I(-1) was found among subjects. Spearman rank-order correlation coefficients (r) revealed significant correlations of peak CK with peak serum protein levels (r = 0.79-0.95), peak changes in MIF (r = 0.73-0.79), RANG (r = 0.69), and CIR (r = 0.91). The higher the peak CK levels, the more profound the abnormality in the MR images and the larger the changes in MR signal intensity (r = 0.90-0.94). It is concluded that the large variability in CK response after exercise seems to be related to the variability in exercise-induced muscle damage.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc80d6a538f64f581760c0b1adc6dd99Test
https://doi.org/10.1055/s-2007-972819Test
