المؤلفون: Jan Bolinder, Peter Arner, Hans Wahrenberg, Anders Wennlund, E Hagström-Toft

المصدر: International Journal of Sports Medicine. 15:408-413

مصطلحات موضوعية: Adult, Glycerol, Male, medicine.medical_specialty, Microdialysis, Epinephrine, Lipolysis, Physical Exertion, Adipose tissue, Physical Therapy, Sports Therapy and Rehabilitation, Physical exercise, Thinking, Electrocardiography, Norepinephrine, chemistry.chemical_compound, Heart Rate, Stress, Physiological, Internal medicine, Adipocyte, Heart rate, medicine, Humans, Orthopedics and Sports Medicine, business.industry, Heart, Venous Plasma, Middle Aged, Endocrinology, Adipose Tissue, chemistry, Exercise Test, Regression Analysis, Female, Extracellular Space, business, Stress, Psychological, medicine.drug

الوصف: The lipolytic and the cardiac responses to 30 min of two different forms of stress--a standardized mental stress test and submaximal bicycle exercise--were investigated in non-obese healthy subjects. This was done by microdialysis of the extracellular space in the abdominal subcutaneous adipose tissue in order to determine lipolysis and electrocardiographic recordings of the heart rate. Glycerol concentrations (lipolysis index) in venous plasma and in adipose tissue dialysate as well as plasma catecholamines and determinations of the heart rate showed marked increases during mental stress (p < 0.001) and physical exercise (p < 0.001), but the patterns of response differed during the two forms of stress. All parameters rose gradually during exercise and decreased continuously in the post-exercise period. During mental stress, however, all parameters peaked within the first 20 min of stimulation and then remained at the same level until after the stress period, when they gradually declined. The maximal increase of glycerol in plasma and adipose tissue during mental stress correlated with the corresponding increase during exercise (r = 0.50-0.60). Such a relationship was not observed with plasma catecholamines or heart rate (r = 0.02-0.29). The peak level of plasma noradrenaline was an independent regressor for the peak levels of glycerol in plasma and adipose tissue as well as for the peak heart rate during mental stress and physical exercise (partial r from 0.35 to 0.64), while the peak level of adrenaline was a regressor for heart rate only during mental stress (partial r = 0.45), when multiple regression analysis was used.(ABSTRACT TRUNCATED AT 250 WORDS)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1676a68703144f2e5c1cd93e40eccbeTest
https://doi.org/10.1055/s-2007-1021079Test

المؤلفون: L. Hellstrom, E Hagström-Toft, Ellen E. Blaak

المساهمون: Humane Biologie, RS: NUTRIM School of Nutrition and Translational Research in Metabolism

المصدر: International Journal of Sports Medicine, 17(6), 439-447. Georg Thieme Verlag

مصطلحات موضوعية: Adult, Glycerol, Male, medicine.medical_specialty, Microdialysis, Adrenergic receptor, medicine.medical_treatment, Adrenergic, Adipose tissue, Physical Therapy, Sports Therapy and Rehabilitation, Physical exercise, Propranolol, Fatty Acids, Nonesterified, Phentolamine, Catecholamines, Internal medicine, medicine, Humans, Orthopedics and Sports Medicine, Exercise, Sex Characteristics, business.industry, Insulin, Lipid Mobilization, Receptors, Adrenergic, Endocrinology, Adipose Tissue, Female, business, medicine.drug

الوصف: Gender differences in adrenergic regulation of lipid mobilization during exercise.Hellstrom L, Blaak E, Hagstrom-Toft E.Department of Medicine, Huddinge Hospital, Karolinska Institute, Sweden.Gender differences in adrenergic regulation of glycerol levels in subcutaneous, abdominal adipose tissue were investigated during submaximal exercise in non-obese, healthy men and women, using microdialysis. During exercise, glycerol levels in venous plasma and venous serum concentrations of free fatty acids increased more in women and reached about two-fold higher values than in men (p < 0.005 or less). Plasma noradrenaline and insulin did not differ between the sexes, whereas plasma adrenaline was two-fold higher in men than in women during exercise (p < 0.01). The glycerol levels in adipose tissue increased during exercise and decreased in the post-exercise period in either sex. When the non-selective beta adrenoceptor blocking agent propranolol was added to the microdialysis perfusate before exercise was initiated, the subsequent increase in dialysate glycerol was significantly diminished in both sexes (p < 0.05). A similar addition of the alpha adrenoceptor blocking agent phentolamine, however, caused a significant further rise in tissue glycerol in men (p < 0.05), whereas the exercise induced increase in glycerol levels remained unaffected by phentolamine in women. Adipose tissue blood flow did not change during exercise in either men or women. In either sex, dialysate lactate levels increased during exercise. This increase was not altered if alpha- or beta-blocking agents were added to the perfusate. In summary, during short term submaximal work, women have a higher increase in circulating lipid than men. This appears, at least in part, to be due to a sex difference in the adrenergic regulation of lipid mobilization during exercise. In men exercise activates beta- as well as alpha-adrenergic receptors in adipose tissue, whereas only beta receptors are activated in adipose tissue of women. Finally, methodological investigations indicate that microdialysis is a valid method for short-term exercise experiments.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::881d3c9bb14b423f1a492241aa6d5dfbTest
https://pubmed.ncbi.nlm.nih.gov/8884419Test