Is the pretransplant C2 an optimum predictor of posttransplant dose for tacrolimus in renal transplantation patients?
| العنوان: | Is the pretransplant C2 an optimum predictor of posttransplant dose for tacrolimus in renal transplantation patients? |
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| المؤلفون: | Praveen Kumar-M, Mukut Minz, Ashish Sharma, Vikram Shetty, Sarbpreet Singh, Smita Pattanaik |
| المصدر: | International Journal of Pharmacokinetics. 4 |
| بيانات النشر: | Future Science Ltd, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | medicine.medical_specialty, business.industry, Urology, medicine.disease, 030226 pharmacology & pharmacy, Tacrolimus, Transplantation, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, medicine, Trough Concentration, business, Kidney transplantation |
| الوصف: | Aim: The study evaluated whether a single dose pretransplant 2-h tacrolimus concentration (C2) could predict the post-transplantation trough concentration (C0). Materials & methods: C2 concentration of tacrolimus was measured after single-dose administration (0.1 mg/kg) in 20 patients, 4–7 days prior to renal transplantation. Tacrolimus C0 monitoring was done on post-transplant day 2, 5, 10, 15 and 30. Results: The mean C2 was 21.79 ± 16.83 ng/ml (4.25–69.46) and the mean C0 obtained 48 h after transplant was 10.2 ± 6.27 (1.63–22.07) ng/ml. The Spearman correlation between C2 and C0 was 0.71 (p 2 could explain only 50% of the total variation in the post-transplant dose requirement hence it may not be sole predictor of the post-transplant dose. |
| تدمد: | 2053-0854 2053-0846 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::19e9394758811846f6b3376ecb5082e3Test https://doi.org/10.4155/ipk-2019-0002Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........19e9394758811846f6b3376ecb5082e3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20530854 20530846 |
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