دورية أكاديمية

Neuroglia targeting nano-therapeutic approaches to rescue aging and neurodegenerating brain.

التفاصيل البيبلوغرافية
العنوان: Neuroglia targeting nano-therapeutic approaches to rescue aging and neurodegenerating brain.
المؤلفون: Sharma, Manju1 (AUTHOR), Aggarwal, Nidhi1 (AUTHOR), Mishra, Jibanananda1,2 (AUTHOR) jibananandamishra@rimt.ac.in, Panda, Jiban Jyoti1 (AUTHOR) jyoti@inst.ac.in
المصدر: International Journal of Pharmaceutics. Apr2024, Vol. 654, pN.PAG-N.PAG. 1p.
مصطلحات موضوعية: *NEUROGLIA, *DNA damage, *OXIDATIVE stress, *THERAPEUTICS, *HOMEOSTASIS
مستخلص: Nanoparticulate therapy in microglia-mediated neuronal protection against (i) DNA breakage; (ii) ROS generation; (iii) mitochondrial dysfunction; (iv) protein aggregation; (v) oxidative DNA damage. [Display omitted] Despite intense efforts at the bench, the development of successful brain-targeting therapeutics to relieve malicious neural diseases remains primitive. The brain, being a beautifully intricate organ, consists of heterogeneous arrays of neuronal and glial cells. Primarily acting as the support system for neuronal functioning and maturation, glial cells have been observed to be engaged more apparently in the progression and worsening of various neural pathologies. The diseased state is often related to metabolic alterations in glial cells, thereby modulating their physiological homeostasis in conjunction with neuronal dysfunction. A plethora of data indicates the effect of oxidative stress, protein aggregation, and DNA damage in neuroglia impairments. Still, a deeper insight is needed to gain a conflict-free understanding in this arena. As a consequence, glial cells hold the potential to be identified as promising targets for novel therapeutic approaches aimed at brain protection. In this review, we describe the recent strides taken in the direction of understanding the impact of oxidative stress, protein aggregation, and DNA damage on neuroglia impairment and neuroglia-directed nanotherapeutic approaches to mitigate the burden of various neural disorders. [ABSTRACT FROM AUTHOR]
قاعدة البيانات: Academic Search Index
الوصف
تدمد:03785173
DOI:10.1016/j.ijpharm.2024.123950