Biofilm inhibition by biocompatible poly(ε-caprolactone) nanocapsules loaded with essential oils and their cyto/genotoxicity to human keratinocyte cell line
| العنوان: | Biofilm inhibition by biocompatible poly(ε-caprolactone) nanocapsules loaded with essential oils and their cyto/genotoxicity to human keratinocyte cell line |
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| المؤلفون: | Monika Mesárošová, Edoardo Napoli, Katarína Kozics, Andrea Puškárová, Domenico Pangallo, Corrada Geraci, Adriana Annušová, Magdaléna Kapustová, Giuseppe Granata, Mária Bučková |
| المصدر: | International journal of pharmaceutics 606 (2021): 120846. doi:10.1016/j.ijpharm.2021.120846 info:cnr-pdr/source/autori:Magdaléna Kapustová, Andrea Puskárová, Mária Bucková, Giuseppe Granata Edoardo Napoli, Adriana Annusová, Monika Mesárosová, Katarína Kozics, Domenico Pangallo, Corrada Geraci/titolo:Biofilm inhibition by biocompatible poly(?-caprolactone) nanocapsules loaded with essential oils and their cyto%2Fgenotoxicity to human keratinocyte cell line/doi:10.1016%2Fj.ijpharm.2021.120846/rivista:International journal of pharmaceutics (Print)/anno:2021/pagina_da:120846/pagina_a:/intervallo_pagine:120846/volume:606 |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Keratinocytes, Polyesters, Pharmaceutical Science, Microbial Sensitivity Tests, behavioral disciplines and activities, Nanocapsules, Cell Line, chemistry.chemical_compound, Poly(?-caprolactone) nanocapsule, mental disorders, Oils, Volatile, Humans, Carvacrol, Candida albicans, Thymol, biology, Chemotype, Origanum, biology.organism_classification, Antimicrobial, Antibiofilm, Anti-Bacterial Agents, HaCaT, Biochemistry, chemistry, Essential oils, Label-free Raman imaging, Biofilms, DNA Damage |
| الوصف: | Essential oils (EOs) of Thymus capitatus (Th) carvacrol chemotype and Origanum vulgare (Or) thymol and carvacrol chemotype were encapsulated in biocompatible poly(e-caprolactone) nanocapsules (NCs). These nanosystems exhibited antibacterial, antifungal, and antibiofilm activities against Staphylococcus aureus, Escherichia coli, and Candida albicans. Th-NCs and Or-NCs were more effective against all tested strains than pure EOs and at the same time were not cytotoxic on HaCaT (T0020001) human keratinocyte cell line. The genotoxic effects of EO-NCs and EOs on HaCaT were evaluated using an alkaline comet assay for the first time, revealing that Th-NCs and Or-NCs did not induce DNA damage compared with untreated control HaCaT cells in vitro after 24 h. The cells morphological changes were assessed by label-free live cell Raman imaging. This study demonstrate the ability of poly(e-caprolactone) nanocapsules loaded with thyme and oregano EOs to reduce microbial and biofilm growth and could be an ecological alternative in the development of new antimicrobial strategies. |
| تدمد: | 1873-3476 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d90832e0ffea18d78e2d0ede5c18d9bcTest https://pubmed.ncbi.nlm.nih.gov/34216769Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....d90832e0ffea18d78e2d0ede5c18d9bc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18733476 |
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