TRANSIENT ISCHEMIA-INDUCED EXPRESSION AND CHANGES OF TYROSINE KINASE A IN THE HIPPOCAMPAL DENTATE GYRUS OF THE GERBIL
| العنوان: | TRANSIENT ISCHEMIA-INDUCED EXPRESSION AND CHANGES OF TYROSINE KINASE A IN THE HIPPOCAMPAL DENTATE GYRUS OF THE GERBIL |
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| المؤلفون: | Chang Ho Kim, Kyung Hwan Bang, Ki-Yeon Yoo, Hak Ju Lee, Moo Ho Won, Beong Ou Lim, Jong Dai Kim, Dae Ho Kim, Tae-Cheon Kang, Hyeon Yong Lee, Jung Hwa Kim, Nak Sul Seong, In Koo Hwang |
| المصدر: | International Journal of Neuroscience. 116:975-989 |
| بيانات النشر: | Informa UK Limited, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Time Factors, animal structures, Blotting, Western, Central nervous system, Ischemia, Hippocampus, Tropomyosin receptor kinase A, Hippocampal formation, Gerbil, Internal medicine, medicine, Animals, Analysis of Variance, Chemistry, General Neuroscience, Dentate gyrus, General Medicine, Protein-Tyrosine Kinases, medicine.disease, Granule cell, Immunohistochemistry, Endocrinology, medicine.anatomical_structure, Gene Expression Regulation, nervous system, Ischemic Attack, Transient, Parahippocampal Gyrus, sense organs, Gerbillinae |
| الوصف: | The present study examined ischemia-related changes in tyrosine kinase A (trkA) immunoreactivity and its protein content in the dentate gyrus after 5 min of transient forebrain ischemia in gerbils. One day after ischemic insult, cresyl violet-positive polymorphic cells showed ischemic degeneration. The ischemia-induced changes in trkA immunoreactivity were found in the polymorphic layer (PL) and granule cell layer (GCL) of the dentate gyrus. In the sham-operated group, trkA immunoreactivity in the dentate gyrus was very weak. From 30 min after ischemia, trkA immunoreactivity was increased in the dentate gyrus and peaked in the dentate gyrus at 12 h after ischemia-reperfusion. Thereafter, trkA immunoreactivity was decreased time-dependently after ischemia-reperfusion. Four days after ischemic insult, trkA immunoreactivity was similar to that of the sham-operated group. In addition, it was found that ischemia-related changes in trkA protein content were similar to the immunohistochemical changes. These results suggest that the chronological changes of trkA in the dentate gyrus after transient forebrain ischemia may be associated with ischemic damage in polymorphic cells of the dentate gyrus. |
| تدمد: | 1543-5245 0020-7454 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d924345df0a55bc7afc52b4db846f1Test https://doi.org/10.1080/00207450600552978Test |
| رقم الانضمام: | edsair.doi.dedup.....95d924345df0a55bc7afc52b4db846f1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15435245 00207454 |
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