التفاصيل البيبلوغرافية
| العنوان: |
A Three-Dimensional Microelectrode Array to Generate Virtual Electrodes for Epiretinal Prosthesis Based on a Modeling Study. |
| المؤلفون: |
Lyu, Qing, Lu, Zhuofan, Li, Heng, Qiu, Shirong, Guo, Jiahui, Sui, Xiaohong, Sun, Pengcheng, Li, Liming, Chai, Xinyu, Lovell, Nigel H. |
| المصدر: |
International Journal of Neural Systems; Mar2020, Vol. 30 Issue 3, pN.PAG-N.PAG, 22p |
| مصطلحات موضوعية: |
PROSTHETICS, THREE-dimensional display systems, ELECTRODES, ELECTRIC fields, VISUAL acuity |
| مستخلص: |
Despite many advances in the development of retinal prostheses, clinical reports show that current retinal prosthesis subjects can only perceive prosthetic vision with poor visual acuity. A possible approach for improving visual acuity is to produce virtual electrodes (VEs) through electric field modulation. Generating controllable and localized VEs is a crucial factor in effectively improving the perceptive resolution of the retinal prostheses. In this paper, we aimed to design a microelectrode array (MEA) that can produce converged and controllable VEs by current steering stimulation strategies. Through computational modeling, we designed a three-dimensional concentric ring–disc MEA and evaluated its performance with different stimulation strategies. Our simulation results showed that electrode–retina distance (ERD) and inter-electrode distance (IED) can dramatically affect the distribution of electric field. Also the converged VEs could be produced when the parameters of the three-dimensional MEA were appropriately set. VE sites can be controlled by manipulating the proportion of current on each adjacent electrode in a current steering group (CSG). In addition, spatial localization of electrical stimulation can be greatly improved under quasi-monopolar (QMP) stimulation. This study may provide support for future application of VEs in epiretinal prosthesis for potentially increasing the visual acuity of prosthetic vision. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
