دورية أكاديمية
Concentration-dependent effects of fullerenol on cultured hippocampal neuron viability
| العنوان: | Concentration-dependent effects of fullerenol on cultured hippocampal neuron viability |
|---|---|
| المؤلفون: | Zha YY, Yang B, Tang ML, Guo QC, Chen JT, Wen LP, Wang M |
| المصدر: | International Journal of Nanomedicine, Vol 2012, Iss default, Pp 3099-3109 (2012) |
| بيانات النشر: | Dove Medical Press, 2012. |
| سنة النشر: | 2012 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | Medicine (General), R5-920 |
| الوصف: | Ying-ying Zha,1 Bo Yang,1 Ming-liang Tang,2 Qiu-chen Guo,1 Ju-tao Chen,1 Long-ping Wen,3 Ming Wang11CAS Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, Hefei, 2Suzhou Institute of NanoTech and NanoBionics, Chinese Academy of Sciences, Suzhou, 3Laboratory of Nano-biology, School of Life Sciences, University of Science and Technology of China, Hefei, People's Republic of ChinaBackground: Recent studies have shown that the biological actions and toxicity of the water-soluble compound, polyhydroxyfullerene (fullerenol), are related to the concentrations present at a particular site of action. This study investigated the effects of different concentrations of fullerenol on cultured rat hippocampal neurons.Methods and results: Fullerenol at low concentrations significantly enhanced hippocampal neuron viability as tested by MTT assay and Hoechst 33342/propidium iodide double stain detection. At high concentrations, fullerenol induced apoptosis confirmed by Comet assay and assessment of caspase proteins.Conclusion: These findings suggest that fullerenol promotes cell death and protects against cell damage, depending on the concentration present. The concentration-dependent effects of fullerenol were mainly due to its influence on the reduction-oxidation pathway.Keywords: fullerenol, nanomaterial, neurotoxicity, neuroprotection, hippocampal neuron |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1176-9114 1178-2013 |
| العلاقة: | http://www.dovepress.com/concentration-dependent-effects-of-fullerenol-on-cultured-hippocampal--a10259Test; https://doaj.org/toc/1176-9114Test; https://doaj.org/toc/1178-2013Test |
| الوصول الحر: | https://doaj.org/article/b5a0daff7e7b43dba1fa0d90c0e86a52Test |
| رقم الانضمام: | edsdoj.b5a0daff7e7b43dba1fa0d90c0e86a52 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 11769114 11782013 |
|---|