دورية أكاديمية
Monocytic Myeloid Derived Suppressor Cells in Hematological Malignancies
| العنوان: | Monocytic Myeloid Derived Suppressor Cells in Hematological Malignancies |
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| المؤلفون: | Giuseppe Alberto Palumbo, Nunziatina Laura Parrinello, Cesarina Giallongo, Emanuele D’Amico, Aurora Zanghì, Fabrizio Puglisi, Concetta Conticello, Annalisa Chiarenza, Daniele Tibullo, Francesco Di Raimondo, Alessandra Romano |
| المصدر: | International Journal of Molecular Sciences, Vol 20, Iss 21, p 5459 (2019) |
| بيانات النشر: | MDPI AG, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | microenvironment, multiple myeloma, chronic lymphatic leukemia, chronic myeloid leukemia, lymphoma mdsc, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | In the era of novel agents and immunotherapies in solid and liquid tumors, there is an emerging need to understand the cross-talk between the neoplastic cells, the host immune system, and the microenvironment to mitigate proliferation, survival, migration and resistance to drugs. In the microenvironment of hematological tumors there are cells belonging to the normal bone marrow, extracellular matrix proteins, adhesion molecules, cytokines, and growth factors produced by both stromal cells and neoplastic cells themselves. In this context, myeloid suppressor cells are an emerging sub-population of regulatory myeloid cells at different stages of differentiation involved in cancer progression and chronic inflammation. In this review, monocytic myeloid derived suppressor cells and their potential clinical implications are discussed to give a comprehensive vision of their contribution to lymphoproliferative and myeloid disorders. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 69784337 |
| العلاقة: | https://www.mdpi.com/1422-0067/20/21/5459Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms20215459 |
| الوصول الحر: | https://doaj.org/article/3a6f2c1b6978433782830ce4995c0229Test |
| رقم الانضمام: | edsdoj.3a6f2c1b6978433782830ce4995c0229 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 69784337 |
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| DOI: | 10.3390/ijms20215459 |