دورية أكاديمية
The Multiple Faces of Integrin–ECM Interactions in Inflammatory Bowel Disease
| العنوان: | The Multiple Faces of Integrin–ECM Interactions in Inflammatory Bowel Disease |
|---|---|
| المؤلفون: | Valentina Garlatti, Sara Lovisa, Silvio Danese, Stefania Vetrano |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 19, p 10439 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | integrin, inflammatory bowel disease, IBD, intestinal fibrosis, inflammation, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Inflammatory Bowel Disease (IBD) comprises a series of chronic and relapsing intestinal diseases, with Crohn’s disease and ulcerative colitis being the most common. The abundant and uncontrolled deposition of extracellular matrix, namely fibrosis, is one of the major hallmarks of IBD and is responsible for the progressive narrowing and closure of the intestine, defined as stenosis. Although fibrosis is usually considered the product of chronic inflammation, the substantial failure of anti-inflammatory therapies to target and reduce fibrosis in IBD suggests that fibrosis might be sustained in an inflammation-independent manner. Pharmacological therapies targeting integrins have recently shown great promise in the treatment of IBD. The efficacy of these therapies mainly relies on their capacity to target the integrin-mediated recruitment and functionality of the immune cells at the damage site. However, by nature, integrins also act as mechanosensitive molecules involved in the intracellular transduction of signals and modifications originating from the extracellular matrix. Therefore, understanding integrin signaling in the context of IBD may offer important insights into mechanisms of matrix remodeling, which are uncoupled from inflammation and could underlie the onset and persistency of intestinal fibrosis. In this review, we present the currently available knowledge on the role of integrins in the etiopathogenesis of IBD, highlighting their role in the context of immune-dependent and independent mechanisms. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| العلاقة: | https://www.mdpi.com/1422-0067/22/19/10439Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms221910439 |
| الوصول الحر: | https://doaj.org/article/acfc5a3a1eed4044a03bb51cd1ec58b2Test |
| رقم الانضمام: | edsdoj.fc5a3a1eed4044a03bb51cd1ec58b2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
|---|---|
| DOI: | 10.3390/ijms221910439 |