The Protective Effects of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-d-Glucoside in the OVA-Induced Asthma Mice Model
| العنوان: | The Protective Effects of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-d-Glucoside in the OVA-Induced Asthma Mice Model |
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| المؤلفون: | Sung-Tae Yee, Yun-Ho Hwang, Hangun Kim, Su-Jin Kim |
| المصدر: | International Journal of Molecular Sciences Volume 19 Issue 12 International Journal of Molecular Sciences, Vol 19, Iss 12, p 4013 (2018) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Inflammation, Pharmacology, Immunoglobulin E, Catalysis, Inorganic Chemistry, lcsh:Chemistry, 03 medical and health sciences, Immune system, airway hyperresponsiveness (AHR), immune system diseases, medicine, Cytotoxic T cell, Physical and Theoretical Chemistry, Molecular Biology, lcsh:QH301-705.5, Spectroscopy, Asthma, medicine.diagnostic_test, biology, business.industry, Organic Chemistry, General Medicine, respiratory system, asthma, medicine.disease, Computer Science Applications, respiratory tract diseases, 030104 developmental biology, Bronchoalveolar lavage, lcsh:Biology (General), lcsh:QD1-999, inflammation, biology.protein, Nasal administration, 2 3 5 4 tetrahydroxystilbene 2 o β d glucoside, medicine.symptom, business, |
| الوصف: | Asthma is an inflammatory disease caused by an imbalance of Th1 and Th2 cells. In general, asthma is characterized by a stronger Th2 response. Most conventional asthma treatment focuses on improving airway flow or suppression of airway inflammation. To reduce the side effects of currently used asthma medicines, we have conducted studies on natural products that have no side effects. 2,3,5,4&prime tetrahydroxystilbene-2-O-&beta d-glucoside (TSG), the main compound of Polygonum multiflorum (PM), has various biological activities, including anti-inflammation and anti-oxidation activities. However, the effect of TSG on asthma has not been studied yet. We examined the effects of TSG on Th2 immune responses using an OVA-induced asthma animal model. OVA-sensitized mice were treated with TSG. 24 h after the last intranasal challenge, airway hyperresponsiveness (AHR) was measured or serum and bronchoalveolar lavage fluid (BALF) were harvested. We measured typical Th1 and Th2 cytokines in serum and BALF. As a result, TSG suppressed Th2 responses, as shown by the lower levels of IL-4, IL-5, total IgE, OVA-specific IgE, and OVA-specific IgG1. On the other hand, TSG increased Th1 responses, as shown by the levels of IFN-gamma. Collectively, these results confirm the potential of TSG for asthma treatment through modulation of inflammatory responses. Considering that the cytotoxic effect of PM extract is due to the cis isomer of TSG, if the effect of TSG on asthma treatment is found to be non-toxic in clinical trials, it would be more effective to use it as a purified component than PM extract as an asthma treatment agent. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1422-0067 |
| DOI: | 10.3390/ijms19124013 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e397698f66afca4fa5b5d68f3b3c1ac0Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e397698f66afca4fa5b5d68f3b3c1ac0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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| DOI: | 10.3390/ijms19124013 |