Association between Serum Soluble CD154 Levels and Mortality in Patients with Malignant Middle Cerebral Artery Infarction
| العنوان: | Association between Serum Soluble CD154 Levels and Mortality in Patients with Malignant Middle Cerebral Artery Infarction |
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| المؤلفون: | Alejandro Jiménez, María M. Martín, Juan M. Borreguero-León, Juan J. Cáceres, Leonardo Lorente, Agustín F. González-Rivero, Luís F. Ramos, Mónica Argueso, Jordi Solé-Violán |
| المصدر: | International Journal of Molecular Sciences, Vol 16, Iss 6, Pp 12147-12158 (2015) International Journal of Molecular Sciences |
| بيانات النشر: | MDPI AG, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Short Note, CD40 Ligand, Gastroenterology, patients, Catalysis, Inorganic Chemistry, lcsh:Chemistry, Internal medicine, Intensive care, Biomarkers, Tumor, Humans, Medicine, In patient, Prospective Studies, Physical and Theoretical Chemistry, CD154, Prospective cohort study, Molecular Biology, lcsh:QH301-705.5, Spectroscopy, Aged, sCD154, business.industry, Cerebral infarction, Organic Chemistry, Case-control study, Glasgow Coma Scale, Infarction, Middle Cerebral Artery, General Medicine, Middle Aged, Prognosis, medicine.disease, cerebral infarction, mortality, Computer Science Applications, Surgery, Logistic Models, lcsh:Biology (General), lcsh:QD1-999, Case-Control Studies, Female, Tumor necrosis factor alpha, business |
| الوصف: | Background: CD154 and its soluble counterpart (sCD154) are proteins of the tumor necrosis factor (TNF) family and exhibit proinflamatory and procoagulant properties. Higher circulating sCD154 levels have been found in ischemic stroke patients than in controls. However, the association between circulating sCD154 levels and mortality in ischemic stroke patients has not been reported, and was the focus of this study. Methods: This was a multicenter, observational and prospective study carried out in six Spanish Intensive Care Units. We measured serum sCD154 from 50 patients with severe malignant middle cerebral artery infarction (MMCAI), defined as Glasgow Coma Scale (GCS) lower than 9, at the moment of the severe MMCAI diagnosis and from 50 healthy controls. The end-point of the study was 30-day mortality. Results: We found higher serum sCD154 levels in patients with severe MMCAI than in healthy controls (p < 0.001). We found higher serum sCD154 levels (p < 0.001) in non-surviving (n = 26) than in surviving MMCAI patients (n = 24). Multiple binomial logistic regression analysis showed that serum sCD154 levels >1.41 ng/mmL were associated with 30-day mortality (OR = 10.25; 95% CI = 2.34–44.95; p = 0.002). Conclusions: The new more important finding of our study was that serum sCD154 levels in MMCAI patients were associated with mortality. |
| اللغة: | English |
| تدمد: | 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bdf16e88dc33b61c24eaf9d67863969Test http://www.mdpi.com/1422-0067/16/6/12147Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2bdf16e88dc33b61c24eaf9d67863969 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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