التفاصيل البيبلوغرافية
| العنوان: |
HPV Meets APOBEC: New Players in Head and Neck Cancer. |
| المؤلفون: |
Riva, Giuseppe, Albano, Camilla, Gugliesi, Francesca, Pasquero, Selina, Pacheco, Sergio Fernando Castillo, Pecorari, Giancarlo, Landolfo, Santo, Biolatti, Matteo, Dell'Oste, Valentina, Pino, Marta del |
| المصدر: |
International Journal of Molecular Sciences; Feb2021, Vol. 22 Issue 3, p1402-1402, 1p |
| مصطلحات موضوعية: |
HEAD & neck cancer, RNA editing, PAPILLOMAVIRUSES, APOLIPOPROTEIN B, SQUAMOUS cell carcinoma, APOLIPOPROTEIN E4 |
| مستخلص: |
Besides smoking and alcohol, human papillomavirus (HPV) is a factor promoting head and neck squamous cell carcinoma (HNSCC). In some human tumors, including HNSCC, a number of mutations are caused by aberrantly activated DNA-modifying enzymes, such as the apolipoprotein B mRNA editing enzyme catalytic polypeptide-like (APOBEC) family of cytidine deaminases. As the enzymatic activity of APOBEC proteins contributes to the innate immune response to viruses, including HPV, the role of APOBEC proteins in HPV-driven head and neck carcinogenesis has recently gained increasing attention. Ongoing research efforts take the cue from two key observations: (1) APOBEC expression depends on HPV infection status in HNSCC; and (2) APOBEC activity plays a major role in HPV-positive HNSCC mutagenesis. This review focuses on recent advances on the role of APOBEC proteins in HPV-positive vs. HPV-negative HNSCC. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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