دورية أكاديمية
Pathophysiology and Molecular Imaging of Diabetic Foot Infections
| العنوان: | Pathophysiology and Molecular Imaging of Diabetic Foot Infections |
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| المؤلفون: | Katie Rubitschung, Amber Sherwood, Andrew P. Crisologo, Kavita Bhavan, Robert W. Haley, Dane K. Wukich, Laila Castellino, Helena Hwang, Javier La Fontaine, Avneesh Chhabra, Lawrence Lavery, Orhan K. Öz |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 21, p 11552 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | diabetic foot infection, molecular imaging, test predictive value, X-ray, optical tomography, DWI, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Diabetic foot infection is the leading cause of non-traumatic lower limb amputations worldwide. In addition, diabetes mellitus and sequela of the disease are increasing in prevalence. In 2017, 9.4% of Americans were diagnosed with diabetes mellitus (DM). The growing pervasiveness and financial implications of diabetic foot infection (DFI) indicate an acute need for improved clinical assessment and treatment. Complex pathophysiology and suboptimal specificity of current non-invasive imaging modalities have made diagnosis and treatment response challenging. Current anatomical and molecular clinical imaging strategies have mainly targeted the host’s immune responses rather than the unique metabolism of the invading microorganism. Advances in imaging have the potential to reduce the impact of these problems and improve the assessment of DFI, particularly in distinguishing infection of soft tissue alone from osteomyelitis (OM). This review presents a summary of the known pathophysiology of DFI, the molecular basis of current and emerging diagnostic imaging techniques, and the mechanistic links of these imaging techniques to the pathophysiology of diabetic foot infections. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| العلاقة: | https://www.mdpi.com/1422-0067/22/21/11552Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms222111552 |
| الوصول الحر: | https://doaj.org/article/218eebccecd34cb0bef4f98b627bd0d2Test |
| رقم الانضمام: | edsdoj.218eebccecd34cb0bef4f98b627bd0d2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms222111552 |