Acute Spinal Cord Injury: A Systematic Review Investigating miRNA Families Involved
| العنوان: | Acute Spinal Cord Injury: A Systematic Review Investigating miRNA Families Involved |
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| المؤلفون: | Pinchi, Enrica, Frati, Alessandro, Cantatore, Santina, D&apos, Errico, Stefano, Russa, Raffaele La, Maiese, Aniello, Palmieri, Mauro, Pesce, Alessandro, Viola, Rocco Valerio, Frati, Paola, Fineschi, Vittorio |
| المساهمون: | Pinchi, E, Frati, A, Cantatore, S, D'Errico, S, Russa, R, Maiese, A, Palmieri, M, Pesce, A, Viola, Rv, Frati, P, Fineschi, V |
| المصدر: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 20, Iss 8, p 1841 (2019) |
| بيانات النشر: | MDPI, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | acute spinal cord injury, animal models, clinical management, miRNAs, pathophysiology, postmortem techniques, Excitotoxicity, Gene Expression, Autopsy, Review, Bioinformatics, medicine.disease_cause, Severity of Illness Index, Catalysis, Inorganic Chemistry, lcsh:Chemistry, microRNA, Severity of illness, medicine, Animals, Humans, animals, biomarkers, disease management, disease models, disease susceptibility, gene expression, humans, microRNAs, severity of illness index, sapinal cord injuries, multigene family, Physical and Theoretical Chemistry, Molecular Biology, Pathological, lcsh:QH301-705.5, Spectroscopy, Spinal Cord Injuries, miRNA, Cause of death, Mechanism (biology), business.industry, animal model, Organic Chemistry, Disease Management, General Medicine, Pathophysiology, Computer Science Applications, Disease Models, Animal, MicroRNAs, lcsh:Biology (General), lcsh:QD1-999, Multigene Family, Disease Susceptibility, business, Biomarkers |
| الوصف: | Acute traumatic spinal cord injury (SCI) involves primary and secondary injury mechanisms. The primary mechanism is related to the initial traumatic damage caused by the damaging impact and this damage is irreversible. Secondary mechanisms, which begin as early as a few minutes after the initial trauma, include processes such as spinal cord ischemia, cellular excitotoxicity, ionic dysregulation, and free radical-mediated peroxidation. SCI is featured by different forms of injury, investigating the pathology and degree of clinical diagnosis and treatment strategies, the animal models that have allowed us to better understand this entity and, finally, the role of new diagnostic and prognostic tools such as miRNA could improve our ability to manage this pathological entity. Autopsy could benefit from improvements in miRNA research: the specificity and sensitivity of miRNAs could help physicians in determining the cause of death, besides the time of death. |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| تدمد: | 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d29b6a0da67825e8123cf75b301b6fbTest http://europepmc.org/articles/PMC6515063Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8d29b6a0da67825e8123cf75b301b6fb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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