Unravelling the Role of Glycogen Synthase Kinase-3 in Alzheimer’s Disease-Related Epileptic Seizures
| العنوان: | Unravelling the Role of Glycogen Synthase Kinase-3 in Alzheimer’s Disease-Related Epileptic Seizures |
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| المؤلفون: | Patrick Kwan, Nigel C. Jones, Runxuan Lin |
| المصدر: | International Journal of Molecular Sciences, Vol 21, Iss 3676, p 3676 (2020) International Journal of Molecular Sciences |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Amyloid beta, Tau protein, tau Proteins, Review, Epileptogenesis, Catalysis, Inorganic Chemistry, lcsh:Chemistry, Epilepsy, Amyloid beta-Protein Precursor, GSK-3, Alzheimer Disease, Seizures, medicine, Amyloid precursor protein, Dementia, Animals, Humans, Hyperphosphorylated tau, Physical and Theoretical Chemistry, Glycogen synthase, Molecular Biology, lcsh:QH301-705.5, Spectroscopy, biology, Organic Chemistry, General Medicine, medicine.disease, Epileptic seizures, Computer Science Applications, Glycogen synthase kinase 3, lcsh:Biology (General), lcsh:QD1-999, biology.protein, Neuroscience, Alzheimer’s disease |
| الوصف: | Alzheimer’s disease (AD) is the most common form of dementia. An increasing body of evidence describes an elevated incidence of epilepsy in patients with AD, and many transgenic animal models of AD also exhibit seizures and susceptibility to epilepsy. However, the biological mechanisms that underlie the occurrence of seizure or increased susceptibility to seizures in AD is unknown. Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that regulates various cellular signaling pathways, and plays a crucial role in the pathogenesis of AD. It has been suggested that GSK-3 might be a key factor that drives epileptogenesis in AD by interacting with the pathological hallmarks of AD, amyloid precursor protein (APP) and tau. Furthermore, seizures may also contribute to the progression of AD through GSK-3. In this way, GSK-3 might be involved in initiating a vicious cycle between AD and seizures. This review aims to summarise the possible role of GSK-3 in the link between AD and seizures. Understanding the role of GSK-3 in AD-associated seizures and epilepsy may help researchers develop new therapeutic approach that can manage seizure and epilepsy in AD patients as well as decelerate the progression of AD. |
| اللغة: | English |
| تدمد: | 1661-6596 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c10a93faa96f6fa14151bdeb0ef6fe49Test https://www.mdpi.com/1422-0067/21/10/3676Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c10a93faa96f6fa14151bdeb0ef6fe49 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16616596 14220067 |
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