Coregulation Analysis of Mechanistic Biomarkers in Autosomal Dominant Polycystic Kidney Disease
| العنوان: | Coregulation Analysis of Mechanistic Biomarkers in Autosomal Dominant Polycystic Kidney Disease |
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| المؤلفون: | Paul Perco, Alexander Dzien, Gert Mayer, Julia Kerschbaum, Benedikt Hofer, Michael A. Rudnicki, Susanne Eder, Johannes Leierer |
| المصدر: | International Journal of Molecular Sciences Volume 22 Issue 13 International Journal of Molecular Sciences, Vol 22, Iss 6885, p 6885 (2021) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Vascular Endothelial Growth Factor A, 030232 urology & nephrology, Angiotensinogen, urologic and male genital diseases, chemistry.chemical_compound, angiogenesis, 0302 clinical medicine, Epidermal growth factor, Medicine, Biology (General), Spectroscopy, Aged, 80 and over, autosomal dominant polycystic kidney disease, General Medicine, Middle Aged, Polycystic Kidney, Autosomal Dominant, female genital diseases and pregnancy complications, Computer Science Applications, Apelin, Vascular endothelial growth factor, Vascular endothelial growth factor A, Chemistry, Female, EGFR signaling, Adult, medicine.medical_specialty, QH301-705.5, Urinary system, Autosomal dominant polycystic kidney disease, Renal function, Catalysis, Article, Inorganic Chemistry, 03 medical and health sciences, mechanistic biomarkers, Internal medicine, Humans, Physical and Theoretical Chemistry, Molecular Biology, QD1-999, Aged, Epidermal Growth Factor, business.industry, urogenital system, Organic Chemistry, medicine.disease, Arginine Vasopressin, 030104 developmental biology, Endocrinology, chemistry, Kidney disorder, business, Biomarkers |
| الوصف: | Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disorder leading to deterioration of kidney function and end stage kidney disease (ESKD). A number of molecular processes are dysregulated in ADPKD but the exact mechanism of disease progression is not fully understood. We measured protein biomarkers being linked to ADPKD-associated molecular processes via ELISA in urine and serum in a cohort of ADPKD patients as well as age, gender and eGFR matched CKD patients and healthy controls. ANOVA and t-tests were used to determine differences between cohorts. Spearman correlation coefficient analysis was performed to assess coregulation patterns of individual biomarkers and renal function. Urinary epidermal growth factor (EGF) and serum apelin (APLN) levels were significantly downregulated in ADPKD patients. Serum vascular endothelial growth factor alpha (VEGFA) and urinary angiotensinogen (AGT) were significantly upregulated in ADPKD patients as compared with healthy controls. Arginine vasopressin (AVP) was significantly upregulated in ADPKD patients as compared with CKD patients. Serum VEGFA and VIM concentrations were positively correlated and urinary EGF levels were negatively correlated with urinary AGT levels. Urinary EGF and AGT levels were furthermore significantly associated with estimated glomerular filtration rate (eGFR) in ADPKD patients. In summary, altered protein concentrations in body fluids of ADPKD patients were found for the mechanistic markers EGF, APLN, VEGFA, AGT, AVP, and VIM. In particular, the connection between EGF and AGT during progression of ADPKD warrants further investigation. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1422-0067 |
| DOI: | 10.3390/ijms22136885 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd240860f2f7ceff71262d3620d4e50dTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fd240860f2f7ceff71262d3620d4e50d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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| DOI: | 10.3390/ijms22136885 |