Effect of Elderberry (Sambucus nigra L.) Extract Supplementation in STZ-Induced Diabetic Rats Fed with a High-Fat Diet
| العنوان: | Effect of Elderberry (Sambucus nigra L.) Extract Supplementation in STZ-Induced Diabetic Rats Fed with a High-Fat Diet |
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| المؤلفون: | Ewelina Król, Virgínia C Lemos, Bartosz Kulczyński, Zbigniew Krejpcio, Sónia A.O. Santos, Adelaide Almeida, Ângelo C. Salvador, Carina Pedrosa Costa, Sílvia M. Rocha, Dawid Szczepankiewicz, Fernanda P M S Bento, Armando J. D. Silvestre |
| المصدر: | International Journal of Molecular Sciences, Vol 18, Iss 1, p 13 (2016) International Journal of Molecular Sciences International Journal of Molecular Sciences; Volume 18; Issue 1; Pages: 13 |
| بيانات النشر: | MDPI AG, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Blood Glucose, Male, 0301 basic medicine, Pharmacology, Sambucus nigra, polar extract, lcsh:Chemistry, elderberry extracts supplementation, Aliivibrio fischeri, lcsh:QH301-705.5, Spectroscopy, biology, Chemistry, Sambucus nigra L, 04 agricultural and veterinary sciences, General Medicine, lipophilic extract, 040401 food science, Computer Science Applications, high-fat diet, Biochemistry, Toxicity, diabetic rats, medicine.drug, Carbohydrate metabolism, Diet, High-Fat, Streptozocin, Article, Catalysis, Diabetes Mellitus, Experimental, Inorganic Chemistry, 03 medical and health sciences, 0404 agricultural biotechnology, Insulin resistance, In vivo, medicine, Animals, Hypoglycemic Agents, Rats, Wistar, Physical and Theoretical Chemistry, Molecular Biology, Plant Extracts, Organic Chemistry, Streptozotocin, biology.organism_classification, medicine.disease, Rats, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, Dietary Supplements, Insulin Resistance, Homeostasis |
| الوصف: | Elderberry (Sambucus nigra L.) lipophilic and polar extract dietary supplementation effects were evaluated according to diabetes management indices, using an in vivo model. A research pipeline was constructed, that ranged from extract preparation, partial chemical characterization and toxicity evaluation, to examining the elderberry extract dietary supplementation effects on biofluid and tissues. Extracts toxicity was screened using an Aliivibrio fischeri bioluminescence model. A concentration of up to 60 mg/L was selected, and rat doses for oral supplementation were computed applying the interspecies correlation between A. fischeri and rats. Wistar type 2 diabetic rats, induced by streptozotocin (STZ), were fed a high-fat diet and supplemented for 4 weeks at doses of 190 and 350 mg/kg body weight/day of lipophilic and polar extract, respectively. As far as we know, lipophilic elderberry extract supplementation was assessed for the first time, while polar extract was administrated at higher doses and for a shorter period compared to previous studies, aiming to evaluate subacute supplementation effects. The polar extract modulated glucose metabolism by correcting hyperglycemia, while the lipophilic extract lowered insulin secretion. Both extracts lowered insulin resistance, without remarkable alterations to hematological indices, sera lipids and sera and tissular trace element homeostasis. In conclusion, elderberries are a potential source of bioactive compounds for formulations to be used as co-adjuvants in diabetes management. |
| وصف الملف: | application/pdf |
| تدمد: | 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42076b28f6bfb083942e85b16ab0942fTest https://doi.org/10.3390/ijms18010013Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....42076b28f6bfb083942e85b16ab0942f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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