Increased Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 Contributes to Epidermal Permeability Barrier Dysfunction in Aged Skin
| العنوان: | Increased Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 Contributes to Epidermal Permeability Barrier Dysfunction in Aged Skin |
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| المؤلفون: | Noo Ri Lee, Beom Jun Kim, Kyong Oh Shin, Eun Jung Kim, Gareth G. Lavery, Hyun Jee Hwang, Kyungho Park, Young Bin Lee, Solam Lee, Chung Hyeok Lee, Eung Ho Choi, Sung Jay Choe |
| المصدر: | International Journal of Molecular Sciences Volume 22 Issue 11 International Journal of Molecular Sciences, Vol 22, Iss 5750, p 5750 (2021) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, 11-beta-hydroxysteroid dehydrogenase type 1, 030207 dermatology & venereal diseases, chemistry.chemical_compound, Mice, 0302 clinical medicine, Corticosterone, 11β-hydroxysteroid dehydrogenase type 1, Biology (General), Spectroscopy, Barrier function, Mice, Knockout, biology, integumentary system, glucocorticoids, General Medicine, Middle Aged, Computer Science Applications, Chemistry, Knockout mouse, Cytokines, Female, Inflammation Mediators, hormones, hormone substitutes, and hormone antagonists, medicine.drug, Adult, medicine.medical_specialty, endocrine system, QH301-705.5, Catalysis, Permeability, Article, Inorganic Chemistry, 03 medical and health sciences, Young Adult, Lipid biosynthesis, Internal medicine, medicine, Animals, Humans, Physical and Theoretical Chemistry, Molecular Biology, QD1-999, Aged, Transepidermal water loss, Organic Chemistry, Hairless, Skin Aging, 030104 developmental biology, Endocrinology, chemistry, Gene Expression Regulation, biology.protein, Cortisone, Epidermis, barrier function, Biomarkers, epidermal lipids |
| الوصف: | Inactive cortisone is converted into active cortisol by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). Excessive levels of active glucocorticoids could deteriorate skin barrier function barrier impairment is also observed in aged skin. In this study, we aimed to determine whether permeability barrier impairment in the aged skin could be related to increased 11β-HSD1 expression. Aged humans (n = 10) showed increased cortisol in the stratum corneum (SC) and oral epithelium, compared to young subjects (n = 10). 11β-HSD1 expression (as assessed via immunohistochemical staining) was higher in the aged murine skin. Aged hairless mice (56-week-old, n = 5) manifested greater transepidermal water loss, lower SC hydration, and higher levels of serum inflammatory cytokines than the young mice (8-week-old, n = 5). Aged 11β-HSD1 knockout mice (n = 11), 11β-HSD1 inhibitor (INHI)-treated aged wild type (WT) mice (n = 5) and young WT mice (n = 10) exhibited reduced SC corticosterone level. Corneodesmosome density was low in WT aged mice (n = 5), but high in aged 11β-HSD1 knockout and aged INHI-treated WT mice. Aged mice exhibited lower SC lipid levels this effect was reversed by INHI treatment. Therefore, upregulation of 11β-HSD1 in the aged skin increases the active-glucocorticoid levels this suppresses SC lipid biosynthesis, leading to impaired epidermal permeability barrier. |
| وصف الملف: | application/pdf |
| تدمد: | 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f8084c8f5c816d4e38a571e81ad199fTest https://pubmed.ncbi.nlm.nih.gov/34072239Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6f8084c8f5c816d4e38a571e81ad199f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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