Synthetic Retinoid Seletinoid G Improves Skin Barrier Function through Wound Healing and Collagen Realignment in Human Skin Equivalents
| العنوان: | Synthetic Retinoid Seletinoid G Improves Skin Barrier Function through Wound Healing and Collagen Realignment in Human Skin Equivalents |
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| المؤلفون: | Il-Hong Bae, Eun-Soo Lee, Daejin Min, Se-Hwa Kim, Yong Deog Hong, Yujin Ahn, Woonggyu Jung, Nok Hyun Park, Chang Seok Lee, Won Seok Park |
| المصدر: | International Journal of Molecular Sciences Volume 21 Issue 9 International Journal of Molecular Sciences, Vol 21, Iss 3198, p 3198 (2020) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Keratinocytes, 0301 basic medicine, Human skin, wound healing, lcsh:Chemistry, 030207 dermatology & venereal diseases, 0302 clinical medicine, Cell Movement, Retinoid, lcsh:QH301-705.5, Spectroscopy, Barrier function, Skin, integumentary system, Chemistry, Dioxolanes, General Medicine, Computer Science Applications, Cell biology, medicine.anatomical_structure, Keratinocyte, Tomography, Optical Coherence, seletinoid G, Cell Survival, Ultraviolet Rays, medicine.drug_class, keratinocyte, Article, Catalysis, Cell Line, Inorganic Chemistry, 03 medical and health sciences, Dermis, medicine, Humans, Physical and Theoretical Chemistry, Molecular Biology, Cell Proliferation, Pyrans, optical coherence tomography, second harmonic generation, Organic Chemistry, HaCaT, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, human skin equivalents, Epidermis, Wound healing |
| الوصف: | The outer epidermal skin is a primary barrier that protects the body from extrinsic factors, such as ultraviolet (UV) radiation, chemicals and pollutants. The complete epithelialization of a wound by keratinocytes is essential for restoring the barrier function of the skin. However, age-related alterations predispose the elderly to impaired wound healing. Therefore, wound-healing efficacy could be also considered as a potent function of an anti-aging reagent. Here, we examine the epidermal wound-healing efficacy of the fourth-generation retinoid, seletinoid G, using HaCaT keratinocytes and skin tissues. We found that seletinoid G promoted the proliferation and migration of keratinocytes in scratch assays and time-lapse imaging. It also increased the gene expression levels of several keratinocyte proliferation-regulating factors. In human skin equivalents, seletinoid G accelerated epidermal wound closure, as assessed using optical coherence tomography (OCT) imaging. Moreover, second harmonic generation (SHG) imaging revealed that seletinoid G recovered the reduced dermal collagen deposition seen in ultraviolet B (UVB)-irradiated human skin equivalents. Taken together, these results indicate that seletinoid G protects the skin barrier by accelerating wound healing in the epidermis and by repairing collagen deficiency in the dermis. Thus, seletinoid G could be a potent anti-aging agent for protecting the skin barrier. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1422-0067 |
| DOI: | 10.3390/ijms21093198 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4187cf7d887e9ee8f5ef57b797e818cTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c4187cf7d887e9ee8f5ef57b797e818c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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| DOI: | 10.3390/ijms21093198 |