Role of Cytokines in Vitiligo: Pathogenesis and Possible Targets for Old and New Treatments
| العنوان: | Role of Cytokines in Vitiligo: Pathogenesis and Possible Targets for Old and New Treatments |
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| المؤلفون: | Francesco Squadrito, Natasha Irrera, Giovanni Pallio, Mario Vaccaro, Domenica Altavilla, Francesco Borgia, Luca Di Bartolomeo, Paolo Custurone, Alessandra Bitto |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 11429, p 11429 (2021) International Journal of Molecular Sciences |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Exonucleases, Keratinocytes, vitiligo, skin, QH301-705.5, Inflammation, Review, Lesion formation, Vitiligo, depigmentation, Bioinformatics, Catalysis, Inorganic Chemistry, Pathogenesis, Biological drugs, Interferon-gamma, Depigmentation, medicine, HLA-DQ beta-Chains, Humans, oxidative stress, biologics, autoimmune diseases, Biology (General), Physical and Theoretical Chemistry, QD1-999, Molecular Biology, Spectroscopy, dermatoses, Biological Products, Pigmentation, Tumor Necrosis Factor-alpha, business.industry, Organic Chemistry, Disease progression, General Medicine, medicine.disease, Computer Science Applications, Chemistry, interleukins, inflammation, Cytokines, Melanocytes, Immune Mediators, medicine.symptom, business, HLA-DRB1 Chains, biological drugs |
| الوصف: | Vitiligo is a chronic autoimmune dermatosis of which the pathogenesis remains scarcely known. A wide variety of clinical studies have been proposed to investigate the immune mediators which have shown the most recurrency. However, such trials have produced controversial results. The aim of this review is to summarize the main factors involved in the pathogenesis of vitiligo, the latest findings regarding the cytokines involved and to evaluate the treatments based on the use of biological drugs in order to stop disease progression and achieve repigmentation. According to the results, the most recurrent studies dealt with inhibitors of IFN-gamma and TNF-alpha. It is possible that, given the great deal of cytokines involved in the lesion formation process of vitiligo, other biologics could be developed in the future to be used as adjuvants and/or to entirely replace the treatments that have proven to be unsatisfactory so far. |
| تدمد: | 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d04a91173a28ee1d149c19894027027Test https://doi.org/10.3390/ijms222111429Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6d04a91173a28ee1d149c19894027027 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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