HIV DNA and dementia in treatment-naïve HIV-1-infected individuals in Bangkok, Thailand
| العنوان: | HIV DNA and dementia in treatment-naïve HIV-1-infected individuals in Bangkok, Thailand |
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| المؤلفون: | Sataporn Thitivichianlert, Cecilia M. Shikuma, Mark S. deSouza, Kevin Robertson, Silvia Ratto-Kim, Robert H. Paul, Victor Valcour, Suwicha Chitpatima, Samart Nidhinandana, Thippawan Chuenchitra, Pasiri Sithinamsuwan, George Watt, Bruce Shiramizu, Suchitra Sukwit |
| المصدر: | International Journal of Medical Sciences International Journal of Medical Sciences, vol 4, iss 1 International journal of medical sciences, vol 4, iss 1 |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Male, cognition, AIDS Dementia Complex, Human immunodeficiency virus (HIV), Lipopolysaccharide Receptors, medicine.disease_cause, Medical and Health Sciences, Pathogenesis, Therapy naive, chemistry.chemical_compound, 0302 clinical medicine, Cognition, Antiretroviral Therapy, Highly Active, Receptors, Leukocytes, 2.1 Biological and endogenous factors, 030212 general & internal medicine, Viral, Aetiology, 0303 health sciences, Short Research Communication, virus diseases, General Medicine, 3. Good health, Infectious Diseases, 6.1 Pharmaceuticals, Cohort, HIV/AIDS, Female, Infection, Adult, IgG, Mononuclear, Antiretroviral Therapy, Biology, Peripheral blood mononuclear cell, human immunodeficiency virus type 1, 03 medical and health sciences, HIV DNA, Clinical Research, medicine, Genetics, Dementia, Humans, Highly Active, 030304 developmental biology, Gastroenterology & Hepatology, Receptors, IgG, Neurosciences, RNA, Evaluation of treatments and therapeutic interventions, DNA, medicine.disease, Virology, Brain Disorders, CD4 Lymphocyte Count, chemistry, Immunology, DNA, Viral, HIV-1, Leukocytes, Mononuclear, dementia |
| الوصف: | High HIV-1 DNA (HIV DNA) levels in peripheral blood mononuclear cells (PBMC) correlate with HIV-1-associated dementia (HAD) in patients on highly active antiretroviral therapy (HAART). If this relationship also exists among HAART-naïve patients, then HIV DNA may be implicated in the pathogenesis of HAD. In this study, we evaluated the relationship between HIV DNA and cognition in subjects naïve to HAART in a neuro AIDS cohort in Bangkok, Thailand. Subjects with and without HAD were recruited and matched for age, gender, education, and CD4 cell count. PBMC and cellular subsets were analyzed for HIV DNA using real-time PCR. The median log(10) HIV DNA copies per 10(6) PBMC for subjects with HAD (n=15) was 4.27, which was higher than that found in subjects without dementia (ND; n=15), 2.28, p |
| وصف الملف: | application/pdf |
| تدمد: | 1449-1907 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ac838687b3adbf55fcb734fb66254fTest https://pubmed.ncbi.nlm.nih.gov/17211496Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....85ac838687b3adbf55fcb734fb66254f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14491907 |
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