التفاصيل البيبلوغرافية
| العنوان: |
The Efficacy and Safety of High-dose Daptomycin in the Treatment of Complicated Skin and Soft Tissue Infections in Asians. |
| المؤلفون: |
Dong, Xiao-meng1 (AUTHOR), Xu, Nan-nan1 (AUTHOR), Yao, Yong-yuan2 (AUTHOR), Guan, Yan-yan3 (AUTHOR), Li, Qing-yan4 (AUTHOR), Zheng, Feng1 (AUTHOR), Chen, Feng-zhe1 (AUTHOR), Wang, Gang1 (AUTHOR) clinicalpaper@163.com |
| المصدر: |
International Journal of Infectious Diseases. Jun2020, Vol. 95, p38-43. 6p. |
| مصطلحات موضوعية: |
*SOFT tissue infections, *ASIANS, *DRUG efficacy, *ANTIBIOTICS, *DRUG dosage, *DOSE-effect relationship in pharmacology, *DAPTOMYCIN, *SKIN infections |
| مصطلحات جغرافية: |
CHINA |
| مستخلص: |
• Totally 155 patients from three medical centers in East China were recruited, including 108 patients in standard-dose group and 47 patients in high-dose group. • This study was a retrospective study, and established strict inclusion criteria. Furthermore, two experienced infectious experts reviewed the cases which met the cSSTIs diagnosis, and excluded the doubtful cases. • The results of multivariate analysis indicated that high-dose daptomycin was an independent effector for early clinical stabilization. • Compared with standard-dose daptomycin, high-dose daptomycin increased the rate of early clinical stabilization in Asian patients with cSSTIs, whereas the incidence of adverse events did not increase. To compare the efficacy and safety of standard-dose (SD) daptomycin with those of high-dose (HD) daptomycin in complicated skin and soft tissue infections (cSSTIs) in an Asian population. Patients from three medical centers diagnosed with cSSTIs were screened in the clinical information system. Patients included in the analysis were divided into two groups: those who received daptomycin at doses ≥ 6 mg/kg (HD group) and those receiving 4 mg/kg (SD group). The demographics and clinical treatment information were analyzed. Overall, 155 patients were recruited, including 108 patients in the SD group and 47 patients in the HD group. The rate of healthcare-associated infections was higher in the HD group (61.70% vs. 37.04%), demonstrating a statistically significant difference (P = 0.005). Compared with the SD group, the HD group had statistically significant early clinical stabilization (72.34% vs 52.78%, P = 0.023). The results of the multivariate analysis indicated that HD daptomycin was an independent effector for early clinical stabilization (HR=0.394, P < 0.001). The rate of drug-related adverse events was equally distributed in the HD and SD groups (36.17% vs. 26.85%, P = 0.243). Compared with SD daptomycin, HD daptomycin increased the rate of early clinical stabilization in Asian patients with cSSTIs, whereas the incidence of adverse events did not increase. [ABSTRACT FROM AUTHOR] |
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