التفاصيل البيبلوغرافية
| العنوان: |
A phase I, open-label, dose-escalation study of amrubicin in combination with lenalidomide and weekly dexamethasone in previously treated adults with relapsed or refractory multiple myeloma. |
| المؤلفون: |
Dinner, Shira, Dunn, Tamara J., Price, Elizabeth, Coutré, Steven E., Gotlib, Jason, Berube, Caroline, Kaufman, Gregory P., Medeiros, Bruno C., Liedtke, Michaela |
| المصدر: |
International Journal of Hematology; Sep2018, Vol. 108 Issue 3, p267-273, 7p |
| مصطلحات موضوعية: |
ANTHRACYCLINES, ANTINEOPLASTIC agents, CLINICAL trials, COMPARATIVE studies, DRUG administration, INTRAVENOUS therapy, RESEARCH methodology, MEDICAL cooperation, MULTIPLE myeloma, ORAL drug administration, RESEARCH, THALIDOMIDE, DISEASE relapse, EVALUATION research, TREATMENT effectiveness, DEXAMETHASONE |
| مستخلص: |
This phase 1 study investigated the safety of the anthracycline amrubicin combined with lenalidomide and dexamethasone in adults with relapsed or refractory multiple myeloma. A standard 3 + 3 design was used. Patients received intravenous amrubicin 40-80 mg/m2 on day one, lenalidomide 15 mg orally on days 1-14, and dexamethasone 40 mg orally weekly on 21 day cycles. 14 patients were enrolled, and completed a median of three cycles. The maximum tolerated dose was not reached. One patient experienced dose limiting toxicity of dizziness and diarrhea. The most frequent non-hematologic toxicity was infection (79%). Serious adverse events included cord compression and sepsis. Three patients (21%) had a partial response or better, and seven (50%) had stable disease. The median duration of response was 4.4 months, and the median progression-free survival was 3 months. Amrubicin combined with lenalidomide and dexamethasone, was safe and demonstrated clinical activity in relapsed or refractory multiple myeloma.Clinicaltrials.gov identifier: NCT01355705. [ABSTRACT FROM AUTHOR] |
|
Copyright of International Journal of Hematology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
