التفاصيل البيبلوغرافية
| العنوان: |
Increased thyroidal fat and goitrous hypothyroidism induced by interferon-γ. |
| المؤلفون: |
Kimura, Hiroaki, Kimura, Miho, Westra, William H., Rose, Noel R., Caturegli, Patrizio |
| المصدر: |
International Journal of Experimental Pathology; Apr2005, Vol. 86 Issue 2, p97-106, 10p |
| مصطلحات موضوعية: |
THYROID gland, FAT, HYPOTHYROIDISM, THYROID diseases, INTERFERONS, THYROIDITIS, AUTOIMMUNITY, MACROPHAGES, IMMUNITY, LYMPHOKINES, RETICULO-endothelial system |
| مستخلص: |
Hashimoto's thyroiditis is associated with a diffuse lymphocytic infiltration of the stroma and a production of several cytokines, such as interferon-γ (IFN-γ). We previously reported that transgenic mice expressing IFN-γ under the control of the thyroglobulin promoter develop primary hypothyroidism. In order to determine the long-term changes induced by IFN-γ in the thyroid gland, we analysed cross-sectionally 202 mice (96 transgenic mice and 106 controls) of 0–650 days of age. Multiple linear regression analysis showed that, after adjusting for age and sex,thyr-IFN-γ transgenic mice were 14% (3 g) smaller (P < 0.0001) and had a 5- to 6-fold bigger thyroid (P < 0.0001) than wild-type littermates. Transgenic thyroids showed striking histopathological changes in follicles, thyrocytes and stroma. Follicles were enlarged, irregular and were lined by thickened, granular and oxyphilic thyrocytes. The stroma contained a moderate and diffuse mononuclear infiltrate– mainly composed of macrophages– and, interestingly, a clear increase in the content of fat. These findings indicate that, in addition to hypothyroidism, chronic exposure of the thyroid to IFN-γ leads also to macrophage infiltration and subsequent adipocyte expansion, suggesting a link between inflammation and fat accumulation. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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