High Risk First Degree Relatives of Type 1 Diabetics: An Association with Increases in CXCR3+ T Memory Cells Reflecting an Enhanced Activity of Th1 Autoimmune Response
| العنوان: | High Risk First Degree Relatives of Type 1 Diabetics: An Association with Increases in CXCR3+ T Memory Cells Reflecting an Enhanced Activity of Th1 Autoimmune Response |
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| المؤلفون: | Ivanka Markovic, N. Rajkovic, Nebojsa Lalic, Marija Macesic, Jelena P. Seferovic, Veljko Jeremic, Katarina Lalic, Aleksandra Jotic, Sandra Aleksic, Dusan Popadic, Tanja Milicic, J. Stanarcic, Ljiljana Lukic, Milorad Civcic |
| المصدر: | International Journal of Endocrinology International Journal of Endocrinology, Vol 2014 (2014) |
| بيانات النشر: | Hindawi Publishing Corporation, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | medicine.medical_specialty, Chemokine, Article Subject, Endocrinology, Diabetes and Metabolism, CCR4, Immunofluorescence staining, CXCR3, lcsh:Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Internal medicine, Medicine, Binary logistic regression analysis, First-degree relatives, 030304 developmental biology, 0303 health sciences, lcsh:RC648-665, biology, Endocrine and Autonomic Systems, business.industry, Healthy subjects, Immunology, biology.protein, Clinical Study, business, 030215 immunology |
| الوصف: | We analyzed the level of (a) CXCR3+(Th1) and CCR4+(Th2) T memory cells (b) interferon-γinducible chemokine (IP-10)(Th1) and thymus and activation-regulated chemokine (TARC)(Th2), in 51 first degree relatives (FDRs) of type 1 diabetics (T1D) (17 high risk FDRs (GADA+, IA-2+) and 34 low risk FDRs (GADA−, IA-2−)), 24 recent-onset T1D (R-T1D), and 18 healthy subjects. T memory subsets were analyzed by using four-color immunofluorescence staining and flowcytometry. IP-10 and TARC were determined by ELISA. High risk FDRs showed higher levels of CXCR3+and lower level of CCR4+T memory cells compared to low risk FDRs (64.98 ± 5.19 versus 42.13 ± 11.11; 29.46 ± 2.83 versus 41.90 ± 8.58%, resp.,P<0.001). Simultaneously, both IP-10 and TARC levels were increased in high risk versus low risk FDRs (160.12 ± 73.40 versus 105.39 ± 71.30; 438.83 ± 120.62 versus 312.04 ± 151.14 pg/mL,P<0.05). Binary logistic regression analysis identified the level of CXCR3+T memory cells as predictors for high risk FDRs, together with high levels of IP-10. The results imply that, in FDRs, the risk for T1D might be strongly influenced by enhanced activity of Th1 and diminished activity of Th2 autoimmune response. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 1687-8345 1687-8337 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20ffcde5a9bbba8c9a204e0c7108ba6Test http://europepmc.org/articles/PMC3979071Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b20ffcde5a9bbba8c9a204e0c7108ba6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16878345 16878337 |
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