Association of the rs3758391 polymorphism in the SIRT1 gene with diabetic nephropathy and decreased estimated glomerular filtration rate (GFR) in a population from southwest Iran
| العنوان: | Association of the rs3758391 polymorphism in the SIRT1 gene with diabetic nephropathy and decreased estimated glomerular filtration rate (GFR) in a population from southwest Iran |
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| المؤلفون: | Mohammad Taha Jalali, Mehrnoosh Zakerkish, Ramin Tavakoli Faradonbeh, Hamid Yaghooti, Ali Karimi Akhormeh, Narges Mohammadtaghvaei |
| المصدر: | International Journal of Diabetes in Developing Countries. 40:99-105 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | medicine.medical_specialty, Creatinine, education.field_of_study, business.industry, Endocrinology, Diabetes and Metabolism, Population, Renal function, medicine.disease, Gastroenterology, Nephropathy, Diabetic nephropathy, chemistry.chemical_compound, chemistry, Internal medicine, Diabetes mellitus, Genotype, Internal Medicine, medicine, business, education, Allele frequency |
| الوصف: | Type 2 diabetes mellitus (T2DM) is a polygenic metabolic disorder. SIRT1 has an essential role in the insulin-signaling pathway and energy homeostasis. SIRT1 exerts protective effects in the kidney cells. We aimed to investigate whether the rs3758391 variant was associated with diabetic nephropathy, measures of kidney function, and BMI in a population with and without diabetes in southwest Iran. The study comprised 132 patients with type 2 diabetes mellitus (T2DM) (with and without nephropathy). They were compared with 66 normal subjects. The subjects were genotyped for the rs3758391 polymorphism by the PCR–RFLP method. Fasting blood glucose, HbA1c, urea, creatinine, and urinary albumin were measured using a biochemistry analyzer. Serum cystatin C levels were measured by ELISA. The genotype distribution and allele frequencies were significantly different between the entirely diabetic group and the healthy subjects (p value |
| تدمد: | 1998-3832 0973-3930 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::2ac561f4b93a0076985b4e78d0eb9532Test https://doi.org/10.1007/s13410-019-00742-1Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........2ac561f4b93a0076985b4e78d0eb9532 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19983832 09733930 |
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