التفاصيل البيبلوغرافية
| العنوان: |
Clinical use of the co-formulation of insulin degludec and insulin aspart. |
| المؤلفون: |
Kumar, A., Awata, T., Bain, S. C., Ceriello, A., Fulcher, G. R., Unnikrishnan, A. G., Arechavaleta, R., Gonzalez‐Gálvez, G., Hirose, T., Home, P. D., Kaku, K., Litwak, L., Madsbad, S., Pinget, M., Mehta, R., Mithal, A., Tambascia, M., Tibaldi, J., Christiansen, J.S. |
| المصدر: |
International Journal of Clinical Practice; Aug2016, Vol. 70 Issue 8, p657-667, 11p, 1 Diagram, 3 Charts, 1 Graph |
| مستخلص: |
Aims: To provide a review of the available data and practical use of insulin degludec with insulin aspart (IDegAsp). Premixed insulins provide basal and prandial glucose control; however, they have an intermediate-acting prandial insulin component and do not provide as effective basal coverage as true long-acting insulins, owing to the physicochemical incompatibility of their individual components, coupled with the inflexibility of adjustment. The molecular structure of the co-formulation of IDegAsp, a novel insulin preparation, allows these two molecules to coexist without affecting their individual pharmacodynamic profiles.Methods: Clinical evidence in phase 2/3 trials of IDegAsp efficacy and safety in type 1 and type 2 diabetes mellitus (T1DM and T2DM) have been assessed and summarised.Results: In people with T2DM, once- and twice-daily dosing provides similar overall glycaemic control (HbA1c ) to current modern insulins, but with lower risk of nocturnal hypoglycaemia. In prior insulin users, glycaemic control was achieved with lower or equal insulin doses vs. other basal+meal-time or premix insulin regimens. In insulin-naïve patients with T2DM, IDegAsp can be started once or twice-daily, based on individual need. People switching from more than once-daily basal or premix insulin therapy can be converted unit-to-unit to once-daily IDegAsp, although this strategy should be assessed by the physician on an individual basis.Conclusions: IDegAsp offers physicians and people with T2DM a simpler insulin regimen than other available basal-bolus or premix-based insulin regimens, with stable daytime basal coverage, a lower rate of hypoglycaemia and some flexibility in injection timing compared with premix insulins. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
